6CCY

Crystal structure of Akt1 in complex with a selective inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RAC-alpha serine/threonine-protein kinase,PIFtide	polymer	343	39958.5	1	UniProt (P31749) UniProt (Q16513) Pfam (PF00069) Pfam (PF00433) In PDB	Homo sapiens (Human)	Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha
2	A	(5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one	non-polymer		571.6	1	Chemie (EX4)
3		water	water		18.0	56	Chemie (HOH)

Sequence modifications

A: 144 - 466 (UniProt: P31749)

PDB	External Database	Details
Gly 141	-	expression tag
Ser 142	-	expression tag
Leu 143	-	expression tag
Ser 199	Asn 199	engineered mutation
Pro 396	Ser 396	engineered mutation
Ser 397	Glu 397	engineered mutation
Val 433	Thr 433	engineered mutation

A: 467 - 481 (UniProt: Q16513)

PDB	External Database	Details
Glu 482	-	expression tag
Gly 483	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	39958.5
Non-Polymers*	Number of molecules	1
	Total formula weight	571.6
All*	Total formula weight	40530.1

*Water molecules are not included.