1M59
 
 | | Crystal Structure of P40V Mutant of Trypsin-solubilized Fragment of Cytochrome b5 | | 分子名称: | Cytochrome b5, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Wang, Z.-Q, Wu, J, Wang, Y.-H, Qian, W, Xie, Y, Xia, Z.-X, Huang, Z.-X. | | 登録日 | 2002-07-09 | | 公開日 | 2003-03-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Proline40 is essential to maintaining cytochrome b5 stability and its electron transfer with cytochrome c
Chin.J.Chem., 20, 2002
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6O5X
 | | Crystal Structure of multi-drug resistant HIV-1 protease PR-S17 with substrate analog CA-p2 | | 分子名称: | CHLORIDE ION, HIV-1 protease PR-S17, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, ... | | 著者 | Agniswamy, J, Wang, Y.-F, Weber, I.T. | | 登録日 | 2019-03-04 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues.
Acs Omega, 4, 2019
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4KZM
 | | Crystal Structure of TR3 LBD S553A Mutant | | 分子名称: | GLYCEROL, Nuclear receptor subfamily 4 group A member 1 | | 著者 | Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. | | 登録日 | 2013-05-30 | | 公開日 | 2013-12-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Nat.Chem.Biol., 10, 2014
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6O1N
 | | Cryo-EM structure of TRPV5 (1-660) in nanodisc | | 分子名称: | Transient receptor potential cation channel subfamily V member 5 | | 著者 | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | | 登録日 | 2019-02-21 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
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8HNS
 | | Crystal structure of an anti-CRISPR protein AcrIIC4 in apo form | | 分子名称: | GLYCEROL, anti-CRISPR protein AcrIIC4 | | 著者 | Sun, W, Cheng, Z, Yang, J, Wang, Y. | | 登録日 | 2022-12-08 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8HNT
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5XQ2
 | | Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 5A6 on the guide strand | | 分子名称: | DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(*AP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*AP*GP*AP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), ... | | 著者 | Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, D, Wang, Y. | | 登録日 | 2017-06-06 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | | 主引用文献 | Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
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4KZI
 | | Crystal Structure of TR3 LBD in complex with DPDO | | 分子名称: | 1-(3,5-dimethoxyphenyl)decan-1-one, GLYCEROL, Nuclear receptor subfamily 4 group A member 1 | | 著者 | Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. | | 登録日 | 2013-05-30 | | 公開日 | 2013-12-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Nat.Chem.Biol., 10, 2014
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5XU7
 | | Crystal structure of Escherichia coli holo-[acyl-carrier-protein] synthase (AcpS) | | 分子名称: | CHLORIDE ION, GLYCEROL, Holo-[acyl-carrier-protein] synthase | | 著者 | Liao, Y.P, Wang, D.L, Yin, D.P, Zhang, Q.Y, Wang, Y.M, Wang, D.Q, Zhu, H.X, Chen, S. | | 登録日 | 2017-06-22 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria
To Be Published
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1REO
 | | L-amino acid oxidase from Agkistrodon halys pallas | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AHPLAAO, CITRIC ACID, ... | | 著者 | Zhang, H, Teng, M, Niu, L, Wang, Y, Wang, Y, Liu, Q, Huang, Q, Hao, Q, Dong, Y, Liu, P. | | 登録日 | 2003-11-07 | | 公開日 | 2004-05-04 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom.
Acta Crystallogr.,Sect.D, 60, 2004
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2ZED
 | | Crystal structure of the human glutaminyl cyclase mutant S160A at 1.7 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-12 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEH
 | | Crystal structure of the human glutaminyl cyclase mutant E201Q at 1.8 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-12 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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8DCI
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5XUH
 | | Crystal structure of Escherichia coli holo-[acyl-carrier-protein] synthase (AcpS) D9A mutant in complex with CoA | | 分子名称: | CHLORIDE ION, COENZYME A, GLYCEROL, ... | | 著者 | Liao, Y.P, Wang, D.L, Yin, D.P, Zhang, Q.Y, Wang, Y.M, Wang, D.Q, Zhu, H.X, Chen, S. | | 登録日 | 2017-06-23 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria
To Be Published
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8DCH
 | | Crystal Structure of a highly resistant HIV-1 protease Clinical isolate PR10x with GRL-0519 (tris-tetrahydrofuran as P2 ligand) | | 分子名称: | (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, CHLORIDE ION, GLYCEROL, ... | | 著者 | Wong-Sam, A.E, Wang, Y.-F, Weber, I.T. | | 登録日 | 2022-06-16 | | 公開日 | 2022-10-05 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics.
J.Mol.Graph.Model., 117, 2022
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6PC4
 | | Tubulin-RB3_SLD-TTL in complex with compound ABI-274 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | | 登録日 | 2019-06-15 | | 公開日 | 2020-04-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | | 主引用文献 | Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
J.Med.Chem., 63, 2020
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4KZJ
 | | Crystal Structure of TR3 LBD L449W Mutant | | 分子名称: | GLYCEROL, Nuclear receptor subfamily 4 group A member 1 | | 著者 | Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. | | 登録日 | 2013-05-30 | | 公開日 | 2013-12-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Nat.Chem.Biol., 10, 2014
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8IRV
 | | Dopamine Receptor D5R-Gs-Rotigotine complex | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | | 登録日 | 2023-03-19 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural genomics of the human dopamine receptor system.
Cell Res., 33, 2023
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8IRT
 | | Dopamine Receptor D3R-Gi-Rotigotine complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | | 登録日 | 2023-03-19 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural genomics of the human dopamine receptor system.
Cell Res., 33, 2023
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8IRS
 | | Dopamine Receptor D2R-Gi-Rotigotine complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | | 登録日 | 2023-03-19 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural genomics of the human dopamine receptor system.
Cell Res., 33, 2023
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8IRR
 | | Dopamine Receptor D1R-Gs-Rotigotine complex | | 分子名称: | CHOLESTEROL, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | | 登録日 | 2023-03-19 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural genomics of the human dopamine receptor system.
Cell Res., 33, 2023
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6IFZ
 | | Type III-A Csm complex, Cryo-EM structure of Csm-CTR2-ssDNA complex | | 分子名称: | CTR2, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ... | | 著者 | You, L, Ma, J, Wang, J, Zhang, X, Wang, Y. | | 登録日 | 2018-09-21 | | 公開日 | 2018-12-12 | | 最終更新日 | 2019-01-23 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference
Cell, 176, 2019
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2ZEN
 | | Crystal structure of the human glutaminyl cyclase mutant D305A at 1.78 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-13 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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5G06
 | | Cryo-EM structure of yeast cytoplasmic exosome | | 分子名称: | EXOSOME COMPLEX COMPONENT CSL4, EXOSOME COMPLEX COMPONENT MTR3, EXOSOME COMPLEX COMPONENT RRP4, ... | | 著者 | Liu, J.J, Niu, C.Y, Wu, Y, Tan, D, Wang, Y, Ye, M.D, Liu, Y, Zhao, W.W, Zhou, K, Liu, Q.S, Dai, J.B, Yang, X.R, Dong, M.Q, Huang, N, Wang, H.W. | | 登録日 | 2016-03-17 | | 公開日 | 2016-06-15 | | 最終更新日 | 2017-08-02 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryoem Structure of Yeast Cytoplasmic Exosome Complex.
Cell Res., 26, 2016
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7WK5
 | | Cryo-EM structure of Omicron S-ACE2, C2 state | | 分子名称: | Angiotensin-converting enzyme 2, Spike glycoprotein | | 著者 | Han, W.Y, Wang, Y.F. | | 登録日 | 2022-01-08 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-03-09 | | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | | 主引用文献 | Molecular basis of SARS-CoV-2 Omicron variant receptor engagement and antibody evasion and neutralization
Biorxiv, 2022
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