6PC4

Tubulin-RB3_SLD-TTL in complex with compound ABI-274

Summary for 6PC4

• Entry DOI: 10.2210/pdb6pc4/pdb
• Related: 6AGK
• Descriptor: Tubulin alpha-1B chain, [2-(4-methylphenyl)-1H-imidazol-4-yl](3,4,5-trimethoxyphenyl)methanone, Tubulin beta-2B chain, ... (11 entities in total)
• Functional Keywords: microtubule inhibitor, colchicine, cancer, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 264486.05

Authors

Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2019-06-15, release date: 2020-04-22, Last modification date: 2024-03-13)

• Primary citation: Chen, H.,Deng, S.,Wang, Y.,Albadari, N.,Kumar, G.,Ma, D.,Li, W.,White, S.W.,Miller, D.D.,Li, W.; Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.; J.Med.Chem., 63:827-846, 2020; PubMed: 31860298; DOI: 10.1021/acs.jmedchem.9b01815

Experimental method

X-RAY DIFFRACTION (2.602 Å)