6AGK

The structure of CH-II-77-tubulin complex

Summary for 6AGK

• Entry DOI: 10.2210/pdb6agk/pdb
• Descriptor: Tubulin alpha-1B chain, [6-(3-hydroxy-4-methylphenyl)pyridin-2-yl](3,4,5-trimethoxyphenyl)methanone, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: tubulin, complex, inhibitor, structural protein
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 6
• Total formula weight: 265165.36

Authors

Chen, H.,Arnst, K.,Wang, Y.,Miller, D.,Li, W. (deposition date: 2018-08-13, release date: 2019-08-21, Last modification date: 2023-11-22)

• Primary citation: Chen, H.,Deng, S.,Wang, Y.,Albadari, N.,Kumar, G.,Ma, D.,Li, W.,White, S.W.,Miller, D.D.,Li, W.; Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.; J.Med.Chem., 63:827-846, 2020; PubMed: 31860298; DOI: 10.1021/acs.jmedchem.9b01815

Experimental method

X-RAY DIFFRACTION (2.8 Å)