6PC4

Tubulin-RB3_SLD-TTL in complex with compound ABI-274

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Tubulin alpha-1B chain	polymer	450	50041.3	2	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) In PDB	Sus scrofa (Pig)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2	B, D	Tubulin beta-2B chain	polymer	445	49999.9	2	UniProt (A0A287AGU7) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (P02554) In PDB	Sus scrofa (Pig)
3	E	Stathmin-4	polymer	143	16844.2	1	UniProt (Q9H169) Pfam (PF00836) In PDB	Homo sapiens (Human)	Stathmin-like protein B3,RB3
4	F	Tubulin Tyrosine Ligase	polymer	384	44378.5	1	UniProt (E1BQ43) In PDB	Gallus gallus (Chicken)
5	A, C	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	A, B, C	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
7	A, C	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
8	B, D	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
9	B	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
10	B, D	[2-(4-methylphenyl)-1H-imidazol-4-yl](3,4,5-trimethoxyphenyl)methanone	non-polymer		352.4	2	Chemie (O91)
11		water	water		18.0	404	Chemie (HOH)

Sequence modifications

E: 5 - 145 (UniProt: Q9H169)

PDB	External Database	Details
Met 3	-	expression tag
Ala 4	-	expression tag

F: 1 - 378 (UniProt: E1BQ43)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	261305.0
Non-Polymers*	Number of molecules	13
	Total formula weight	3181.1
All*	Total formula weight	264486.1

*Water molecules are not included.