2ZEH

Crystal structure of the human glutaminyl cyclase mutant E201Q at 1.8 angstrom resolution

Summary for 2ZEH

• Entry DOI: 10.2210/pdb2zeh/pdb
• Related: 2AFM 2ZED 2ZEE 2ZEF 2ZEG 2ZEL 2ZEM 2ZEN 2ZEO 2ZEP
• Descriptor: Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hydrogen bond network, glutaminyl cyclase, pyroglutamate, site-directed mutagenesis, proton transfer, acyltransferase, glycoprotein, metal-binding, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: Q16769
• Total number of polymer chains: 2
• Total formula weight: 75435.77

Authors

Huang, K.F.,Wang, Y.R.,Chang, E.C.,Chou, T.L.,Wang, A.H. (deposition date: 2007-12-12, release date: 2008-04-22, Last modification date: 2023-11-01)

• Primary citation: Huang, K.F.,Wang, Y.R.,Chang, E.C.,Chou, T.L.,Wang, A.H.; A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.; Biochem.J., 411:181-190, 2008; PubMed: 18072935; DOI: 10.1042/BJ20071073

Experimental method

X-RAY DIFFRACTION (1.8 Å)