8DCH
Crystal Structure of a highly resistant HIV-1 protease Clinical isolate PR10x with GRL-0519 (tris-tetrahydrofuran as P2 ligand)
Summary for 8DCH
| Entry DOI | 10.2210/pdb8dch/pdb |
| Related | 3PWM 3PWR 6DIL 6DJ2 6DJ5 8DCI |
| Descriptor | Protease, (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, CHLORIDE ION, ... (5 entities in total) |
| Functional Keywords | hiv/aids, hiv protease, drug resistant clinical mutant, evolution of drug resistance, distal mutations, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
| Biological source | Human immunodeficiency virus 1 |
| Total number of polymer chains | 2 |
| Total formula weight | 22336.83 |
| Authors | Wong-Sam, A.E.,Wang, Y.-F.,Weber, I.T. (deposition date: 2022-06-16, release date: 2022-10-05, Last modification date: 2023-10-18) |
| Primary citation | Wong-Sam, A.,Wang, Y.F.,Kneller, D.W.,Kovalevsky, A.Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics. J.Mol.Graph.Model., 117:108315-108315, 2022 Cited by PubMed: 36108568DOI: 10.1016/j.jmgm.2022.108315 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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