6DJ2

HIV-1 protease with single mutation L76V in complex with Lopinavir

Summary for 6DJ2

Entry DOI	10.2210/pdb6dj2/pdb
Related	2IEN 6DIF 6DIL 6DJ1
Descriptor	HIV-1 protease, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	antiviral agents, protein-inhibitor structures, hiv drug resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22211.45
Authors	Wang, Y.-F.,Wong-Sam, A.E.,Zhang, Y.,Weber, I.T. (deposition date: 2018-05-24, release date: 2018-10-17, Last modification date: 2023-10-11)
Primary citation	Wong-Sam, A.,Wang, Y.F.,Zhang, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease. ACS Omega, 3:12132-12140, 2018 Cited by PubMed: 30288468 DOI: 10.1021/acsomega.8b01683 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation