6DJ2
HIV-1 protease with single mutation L76V in complex with Lopinavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 protease | polymer | 99 | 10726.6 | 2 | UniProt (Q5RZ08) Pfam (PF00077) UniProt (by SIFTS) (P04585) | Human immunodeficiency virus 1 | |
| 2 | C (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 3 | D, F, G (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 4 | E (B) | N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE | non-polymer | 628.8 | 1 | Chemie (AB1) PubChem (3817) PubChem (6850809) PubChem (17753816) PubChem (46930986) PubChem (44402181) PubChem (44585174) PubChem (45357371) PubChem (46782073) PubChem (66509096) PubChem (68490226) PubChem (92727) PubChem (70829193) PubChem (52987589) PubChem (6540554) PubChem (124349221) PubChem (59651326) PubChem (169442991) PubChem (60039264) PubChem (76968402) PubChem (86574898) PubChem (93971976) PubChem (124349222) PubChem (124349223) PubChem (129168894) PubChem (133109001) PubChem (155002926) PubChem (171370625) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q5RZ08)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Ile 33 | Leu 33 | engineered mutation |
| Ile 63 | Leu 63 | engineered mutation |
| Ala 67 | Cys 67 | engineered mutation |
| Val 76 | Leu 76 | engineered mutation |
| Ala 95 | Cys 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21453.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 758.2 | |
| All* | Total formula weight | 22211.5 |
