2IEN
Crystal structure analysis of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017)
Replaces: 1S6GSummary for 2IEN
Entry DOI | 10.2210/pdb2ien/pdb |
Related | 2IDW 2IEO |
Descriptor | Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | hiv-1 protease, dimer, inhibitor, uic-94017, tmc114, darunavir, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22427.21 |
Authors | Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Manna, D.,Hussain, A.K.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2006-09-19, release date: 2006-10-03, Last modification date: 2023-08-30) |
Primary citation | Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Hussain, A.K.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T. High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains. J.Mol.Biol., 338:341-352, 2004 Cited by PubMed: 15066436DOI: 10.1016/j.jmb.2004.02.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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