2IEN

Crystal structure analysis of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017)

Replaces:  1S6G

Summary for 2IEN

• Entry DOI: 10.2210/pdb2ien/pdb
• Related: 2IDW 2IEO
• Descriptor: Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: hiv-1 protease, dimer, inhibitor, uic-94017, tmc114, darunavir, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22427.21

Authors

Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Manna, D.,Hussain, A.K.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2006-09-19, release date: 2006-10-03, Last modification date: 2023-08-30)

• Primary citation: Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Hussain, A.K.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T.; High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.; J.Mol.Biol., 338:341-352, 2004; PubMed: 15066436; DOI: 10.1016/j.jmb.2004.02.052

Experimental method

X-RAY DIFFRACTION (1.3 Å)