7F77
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![BU of 7f77 by Molmil](/molmil-images/mine/7f77) | Crystal structure of glutamate dehydrogenase 3 from Candida albicans | Descriptor: | Glutamate dehydrogenase | Authors: | Li, N, Wang, W, Zeng, X, Liu, M, Li, M, Li, C, Wang, M. | Deposit date: | 2021-06-28 | Release date: | 2021-07-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.086 Å) | Cite: | Crystal structure of glutamate dehydrogenase 3 from Candida albicans. Biochem.Biophys.Res.Commun., 570, 2021
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7F79
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![BU of 7f79 by Molmil](/molmil-images/mine/7f79) | Crystal structure of glutamate dehydrogenase 3 from Candida albicans in complex with alpha-ketoglutarate and NADPH | Descriptor: | 2-OXOGLUTARIC ACID, GLYCEROL, Glutamate dehydrogenase, ... | Authors: | Li, N, Wang, W, Zeng, X, Liu, M, Li, M, Li, C, Wang, M. | Deposit date: | 2021-06-28 | Release date: | 2021-07-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of glutamate dehydrogenase 3 from Candida albicans. Biochem.Biophys.Res.Commun., 570, 2021
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7E1V
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![BU of 7e1v by Molmil](/molmil-images/mine/7e1v) | Cryo-EM structure of apo hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, CARDIOLIPIN, ... | Authors: | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | Deposit date: | 2021-02-03 | Release date: | 2021-10-13 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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7E1X
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![BU of 7e1x by Molmil](/molmil-images/mine/7e1x) | Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in presence of TB47 | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, 5-methoxy-2-methyl-~{N}-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide, ... | Authors: | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | Deposit date: | 2021-02-03 | Release date: | 2021-10-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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7E1W
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![BU of 7e1w by Molmil](/molmil-images/mine/7e1w) | Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in the presence of Q203 | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, 6-chloranyl-2-ethyl-N-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide, ... | Authors: | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | Deposit date: | 2021-02-03 | Release date: | 2021-10-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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5XKU
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![BU of 5xku by Molmil](/molmil-images/mine/5xku) | Crystal structure of hemagglutinin globular head from an H7N9 influenza virus in complex with a neutralizing antibody HNIgGA6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HNIgGA6 heavy chain, HNIgGA6 light chain, ... | Authors: | Chen, C, Wang, J, Wang, W, Gao, X, Cui, S, Jin, Q. | Deposit date: | 2017-05-09 | Release date: | 2017-11-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural Insight into a Human Neutralizing Antibody against Influenza Virus H7N9 J. Virol., 92, 2018
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1T70
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![BU of 1t70 by Molmil](/molmil-images/mine/1t70) | Crystal structure of a novel phosphatase from Deinococcus radiodurans | Descriptor: | Phosphatase | Authors: | Shin, D.H, Wang, W, Kim, R, Yokota, H, Kim, S.H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-05-07 | Release date: | 2004-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and enzymatic characterization of DR1281: A calcineurin-like phosphoesterase from Deinococcus radiodurans. Proteins, 70, 2008
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7V4Y
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![BU of 7v4y by Molmil](/molmil-images/mine/7v4y) | TTHA1264/TTHA1265 complex | Descriptor: | Putative zinc protease, ZINC ION, Zinc-dependent peptidase | Authors: | Xu, M, Xu, Q, Ran, T, Wang, W, Sun, B, Wang, Q. | Deposit date: | 2021-08-16 | Release date: | 2022-06-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of TTHA1265 and TTHA1264/TTHA1265 complex reveal an intrinsic heterodimeric assembly. Int.J.Biol.Macromol., 207, 2022
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7VIB
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![BU of 7vib by Molmil](/molmil-images/mine/7vib) | Crystal structure of human ACE2 and GX/P2V RBD | Descriptor: | Angiotensin-converting enzyme 2, Spike glycoprotein, ZINC ION | Authors: | Guo, Y, Cao, W, Jia, N, Wang, W, Yuan, S, Wang, Y. | Deposit date: | 2021-09-26 | Release date: | 2022-10-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of human ACE2 and GX/P2V RBD To Be Published
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6ZRU
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![BU of 6zru by Molmil](/molmil-images/mine/6zru) | Crystal structure of SARS CoV2 main protease in complex with inhibitor Boceprevir | Descriptor: | DIMETHYL SULFOXIDE, Main Protease, boceprevir (bound form) | Authors: | Oerlemans, R, Wang, W, Lunev, S, Domling, A, Groves, M.R. | Deposit date: | 2020-07-14 | Release date: | 2020-08-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Repurposing the HCV NS3-4A protease drug boceprevir as COVID-19 therapeutics. Rsc Med Chem, 12, 2020
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6ZRT
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![BU of 6zrt by Molmil](/molmil-images/mine/6zrt) | Crystal structure of SARS CoV2 main protease in complex with inhibitor Telaprevir | Descriptor: | (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, DIMETHYL SULFOXIDE, Main Protease | Authors: | Oerlemans, R, Wang, W, Lunev, S, Domling, A, Groves, M.R. | Deposit date: | 2020-07-14 | Release date: | 2020-08-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Repurposing the HCV NS3-4A protease drug boceprevir as COVID-19 therapeutics. Rsc Med Chem, 12, 2020
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5DEW
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![BU of 5dew by Molmil](/molmil-images/mine/5dew) | Crystal structure of PAK1 in complex with an inhibitor compound 5 | Descriptor: | 8-[(trans-4-aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7(8H)-one, Serine/threonine-protein kinase PAK 1 | Authors: | Oh, A, Tam, C, Wang, W. | Deposit date: | 2015-08-26 | Release date: | 2016-09-21 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Design of Selective PAK1 Inhibitor G-5555: Improving Proper-ties by Employing an Unorthodox Low-pKa Polar Moiety To Be Published
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7WMW
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![BU of 7wmw by Molmil](/molmil-images/mine/7wmw) | |
7WN8
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![BU of 7wn8 by Molmil](/molmil-images/mine/7wn8) | Crystal structure of antibody (BC31M5) binds to CD47 | Descriptor: | BC31M5 Fab Heavy chain, BC31M5 Fab Light chain, Leukocyte surface antigen CD47, ... | Authors: | Li, Y, Wang, W, Sui, J, Zhang, S. | Deposit date: | 2022-01-17 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety. J Hematol Oncol, 16, 2023
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7WMX
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![BU of 7wmx by Molmil](/molmil-images/mine/7wmx) | |
7WMY
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![BU of 7wmy by Molmil](/molmil-images/mine/7wmy) | |
7WMZ
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![BU of 7wmz by Molmil](/molmil-images/mine/7wmz) | |
8IKJ
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![BU of 8ikj by Molmil](/molmil-images/mine/8ikj) | Cryo-EM structure of the inactive CD97 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G protein-coupled receptor E5,Soluble cytochrome b562,Adhesion G protein-coupled receptor E5 subunit beta | Authors: | Mao, C, Zhao, R, Dong, Y, Gao, M, Chen, L, Zhang, C, Xiao, P, Guo, J, Qin, J, Shen, D, Ji, S, Zang, S, Zhang, H, Wang, W, Shen, Q, Sun, P, Zhang, Y. | Deposit date: | 2023-02-28 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Conformational transitions and activation of the adhesion receptor CD97. Mol.Cell, 84, 2024
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7UFZ
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![BU of 7ufz by Molmil](/molmil-images/mine/7ufz) | Crystal structure of TDP1 complexed with compound XZ768 | Descriptor: | (4-{[(4S)-2-phenylimidazo[1,2-a]pyridin-3-yl]amino}phenyl)phosphonic acid, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | Authors: | Lountos, G.T, Zhao, X.Z, Wang, W, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. | Deposit date: | 2022-03-23 | Release date: | 2023-04-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.559 Å) | Cite: | Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1. Front Chem, 10, 2022
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7UFY
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![BU of 7ufy by Molmil](/molmil-images/mine/7ufy) | Crystal structure of TDP1 complexed with compound XZ766 | Descriptor: | 1,2-ETHANEDIOL, Tyrosyl-DNA phosphodiesterase 1, [(4-{[(4S)-2,7-diphenylimidazo[1,2-a]pyridin-3-yl]amino}phenyl)methyl]phosphonic acid | Authors: | Lountos, G.T, Zhao, X.Z, Wang, W, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. | Deposit date: | 2022-03-23 | Release date: | 2023-04-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.584 Å) | Cite: | Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1. Front Chem, 10, 2022
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7XW9
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![BU of 7xw9 by Molmil](/molmil-images/mine/7xw9) | Cryo-EM structure of the TRH-bound human TRHR-Gq complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | Authors: | Ji, S, Dong, Y, Chen, L, Zang, S, Shen, D, Guo, J, Qin, J, Zhang, H, Wang, W, Shen, Q, Mao, C, Zhang, Y. | Deposit date: | 2022-05-26 | Release date: | 2022-12-28 | Last modified: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular basis for the activation of thyrotropin-releasing hormone receptor. Cell Discov, 8, 2022
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7WIG
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![BU of 7wig by Molmil](/molmil-images/mine/7wig) | Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | Deposit date: | 2022-01-03 | Release date: | 2022-06-01 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res., 32, 2022
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7WIC
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![BU of 7wic by Molmil](/molmil-images/mine/7wic) | Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | Deposit date: | 2022-01-03 | Release date: | 2022-06-01 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res., 32, 2022
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7VMU
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![BU of 7vmu by Molmil](/molmil-images/mine/7vmu) | Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody | Descriptor: | Spike protein S1, scFv E4 | Authors: | Guo, Y, Wang, W, Jiao, P, Yang, H, Rao, Z, Cheng, G. | Deposit date: | 2021-10-09 | Release date: | 2021-11-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants. Cell Biosci, 12, 2022
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