7UFY
Crystal structure of TDP1 complexed with compound XZ766
Summary for 7UFY
Entry DOI | 10.2210/pdb7ufy/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 1, [(4-{[(4S)-2,7-diphenylimidazo[1,2-a]pyridin-3-yl]amino}phenyl)methyl]phosphonic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | phosphodiesterase, dna binding protein, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 105598.04 |
Authors | Lountos, G.T.,Zhao, X.Z.,Wang, W.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke, T.R. (deposition date: 2022-03-23, release date: 2023-04-12, Last modification date: 2023-10-25) |
Primary citation | Zhao, X.Z.,Wang, W.,Lountos, G.T.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke Jr., T.R. Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1. Front Chem, 10:910953-910953, 2022 Cited by PubMed: 36051621DOI: 10.3389/fchem.2022.910953 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.584 Å) |
Structure validation
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