5DEW

Crystal structure of PAK1 in complex with an inhibitor compound 5

Summary for 5DEW

• Entry DOI: 10.2210/pdb5dew/pdb
• Related: 5DEY 5DFP
• Descriptor: Serine/threonine-protein kinase PAK 1, 8-[(trans-4-aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q13153
• Total number of polymer chains: 2
• Total formula weight: 67580.59

Authors

Oh, A.,Tam, C.,Wang, W. (deposition date: 2015-08-26, release date: 2016-09-21, Last modification date: 2024-03-06)

• Primary citation: Ndubaku, C.O.; Design of Selective PAK1 Inhibitor G-5555: Improving Proper-ties by Employing an Unorthodox Low-pKa Polar Moiety; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)