7VMU

Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody

Summary for 7VMU

• Entry DOI: 10.2210/pdb7vmu/pdb
• Descriptor: scFv E4, Spike protein S1 (2 entities in total)
• Functional Keywords: sars-cov-2 variants, covid-19, neutralizing antibody, phage display library, antibody engineering, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 45891.05

Authors

Guo, Y.,Wang, W.,Jiao, P.,Yang, H.,Rao, Z.,Cheng, G. (deposition date: 2021-10-09, release date: 2021-11-03, Last modification date: 2024-10-30)

Primary citation

Li, L.,Gao, M.,Jiao, P.,Zu, S.,Deng, Y.Q.,Wan, D.,Cao, Y.,Duan, J.,Aliyari, S.R.,Li, J.,Shi, Y.,Rao, Z.,Qin, C.F.,Guo, Y.,Cheng, G.,Yang, H.
Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants.
Cell Biosci, 12:63-63, 2022

PubMed Abstract: Neutralizing antibodies are approved drugs to treat coronavirus disease-2019 (COVID-19) patients, yet mutations in severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants may reduce the antibody neutralizing activity. New monoclonal antibodies (mAbs) and antibody remolding strategies are recalled in the battle with COVID-19 epidemic.

PubMed: 35581593
DOI: 10.1186/s13578-022-00794-7

Experimental method

X-RAY DIFFRACTION (2.89 Å)