7WN8

Crystal structure of antibody (BC31M5) binds to CD47

Summary for 7WN8

• Entry DOI: 10.2210/pdb7wn8/pdb
• Descriptor: Leukocyte surface antigen CD47, BC31M5 Fab Heavy chain, BC31M5 Fab Light chain, ... (5 entities in total)
• Functional Keywords: fab, human cd47, complex, antitumor protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 167621.56

Authors

Li, Y.,Wang, W.,Sui, J.,Zhang, S. (deposition date: 2022-01-17, release date: 2023-01-25, Last modification date: 2024-10-23)

Primary citation

Li, Y.,Liu, J.,Chen, W.,Wang, W.,Yang, F.,Liu, X.,Sheng, Y.,Du, K.,He, M.,Lyu, X.,Li, H.,Zhao, L.,Wei, Z.,Wang, F.,Zheng, S.,Sui, J.
A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety.
J Hematol Oncol, 16:2-2, 2023

PubMed Abstract: The antiphagocytic molecule CD47 is overexpressed in a wide variety of cancer cells, and antibodies targeting CD47 for cancer therapies are currently under intensive investigation. However, owing to the ubiquitous expression of CD47 on healthy cells, anti-CD47 therapies often achieve only weak therapeutic benefits and can induce severe side effects. Here, we report the generation of a pH-dependent anti-CD47 antibody (BC31M4) which selectively binds to tumors under the acidic solid tumor microenvironment.

PubMed: 36650558
DOI: 10.1186/s13045-023-01399-4

Experimental method

X-RAY DIFFRACTION (2.8 Å)