7UFZ

Crystal structure of TDP1 complexed with compound XZ768

Summary for 7UFZ

• Entry DOI: 10.2210/pdb7ufz/pdb
• Descriptor: Tyrosyl-DNA phosphodiesterase 1, (4-{[(4S)-2-phenylimidazo[1,2-a]pyridin-3-yl]amino}phenyl)phosphonic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, dna binding protein, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 106226.57

Authors

Lountos, G.T.,Zhao, X.Z.,Wang, W.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke, T.R. (deposition date: 2022-03-23, release date: 2023-04-12, Last modification date: 2023-10-25)

• Primary citation: Zhao, X.Z.,Wang, W.,Lountos, G.T.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke Jr., T.R.; Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1.; Front Chem, 10:910953-910953, 2022; PubMed: 36051621; DOI: 10.3389/fchem.2022.910953

Experimental method

X-RAY DIFFRACTION (1.559 Å)