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PDB: 50 件
7Z3R
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BU of 7z3r by Molmil
Crystal structure of the mouse leptin:LepR-IgCRH2 complex to 2.95 A resolution.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
著者Verstraete, K, Verschueren, K, Savvides, S.N, Tsirigotaki, A.
登録日2022-03-02
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.951 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
7Z3Q
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BU of 7z3q by Molmil
Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Verschueren, K, Alexandra, T, Savvides, S.N.
登録日2022-03-02
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.617 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AV2
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BU of 8av2 by Molmil
Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin receptor, SULFATE ION, ...
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
5J13
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BU of 5j13 by Molmil
Structural basis for TSLP antagonism by the therapeutic antibody Tezepelumab (MEDI9929 / AMG-157)
分子名称: SULFATE ION, Thymic stromal lymphopoietin, anti-TSLP Fab-fragment, ...
著者Verstraete, K, Savvides, S.N.
登録日2016-03-28
公開日2017-04-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Nat Commun, 8, 2017
5J11
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BU of 5j11 by Molmil
Structure of human TSLP in complex with TSLPR and IL-7Ralpha
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, ...
著者Verstraete, K, Savvides, S.N.
登録日2016-03-28
公開日2017-04-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Nat Commun, 8, 2017
5J12
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BU of 5j12 by Molmil
Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, ...
著者Verstraete, K, Savvides, S.N.
登録日2016-03-28
公開日2017-04-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha
To Be Published
8AVD
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BU of 8avd by Molmil
Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement)
分子名称: Leptin, Leptin receptor, NICKEL (II) ION
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (4.42 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVO
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BU of 8avo by Molmil
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model).
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (6.84 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVF
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BU of 8avf by Molmil
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model)
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (6.45 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVC
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BU of 8avc by Molmil
Mouse leptin:LEP-R complex cryoEM structure (3:3 model)
分子名称: Leptin, Leptin receptor, NICKEL (II) ION
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVE
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BU of 8ave by Molmil
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (5.62 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVB
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BU of 8avb by Molmil
Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model).
分子名称: Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-08-26
公開日2023-04-05
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (4.43 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8B7Q
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BU of 8b7q by Molmil
Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
著者Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日2022-09-30
公開日2023-04-05
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (4.02 Å)
主引用文献Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
6QRN
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BU of 6qrn by Molmil
Galectin-10 complexed with ribose
分子名称: Galectin-10, beta-D-ribopyranose
著者Verstraete, K, Verschueren, K.H.G.
登録日2019-02-19
公開日2019-06-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6QCL
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BU of 6qcl by Molmil
Citryl-CoA lyase core module of Chlorobium limicola ATP citrate lyase in complex with acetyl-CoA and L-malate
分子名称: (2S)-2-hydroxybutanedioic acid, ACETYL COENZYME *A, ATP-citrate lyase alpha-subunit, ...
著者Verstraete, K, Verschueren, K.
登録日2018-12-28
公開日2019-04-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6QFB
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BU of 6qfb by Molmil
Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, CITRATE ANION, ...
著者Verstraete, K, Verschueren, K.
登録日2019-01-09
公開日2019-04-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
3QS9
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BU of 3qs9 by Molmil
Crystal structure of a human Flt3 ligand-receptor ternary complex
分子名称: FL cytokine receptor, SL cytokine
著者Verstraete, K, Savvides, S.N.
登録日2011-02-20
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (7.8 Å)
主引用文献Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.
Blood, 118, 2011
3QS7
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BU of 3qs7 by Molmil
Crystal structure of a human Flt3 ligand-receptor ternary complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FL cytokine receptor, SL cytokine
著者Verstraete, K, Savvides, S.N.
登録日2011-02-19
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (4.3 Å)
主引用文献Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.
Blood, 118, 2011
6GLW
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BU of 6glw by Molmil
Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 1D11
分子名称: ACETATE ION, Fab 1D11 - Heavy chain, Fab 1D11 - Light chain, ...
著者Verstraete, K, Verschueren, K, Savvides, S.N.
登録日2018-05-23
公開日2019-06-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GKT
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BU of 6gkt by Molmil
X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu
分子名称: Galectin-10, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ...
著者Verstraete, K, Verschueren, K, Savvides, S.N.
登録日2018-05-21
公開日2019-06-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GLX
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BU of 6glx by Molmil
Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 4E8
分子名称: Fab 4E8 - Heavy chain, Fab 4E8 - Light chain, Galectin-10
著者Verstraete, K, Verschueren, K, Savvides, S.N.
登録日2018-05-23
公開日2019-06-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.396 Å)
主引用文献Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GKU
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BU of 6gku by Molmil
Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 6F5
分子名称: CALCIUM ION, Fab 6F5 - Heavy Chain, Fab 6F5 - Light chain, ...
著者Verstraete, K, Verschueren, K, Savvides, S.N.
登録日2018-05-21
公開日2019-06-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GKS
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BU of 6gks by Molmil
X-ray structure determined from recombinant Charcot-Leyden crystal
分子名称: GLYCEROL, Galectin-10
著者Verstraete, K, Verschueren, K, Savvides, S.N.
登録日2018-05-21
公開日2019-06-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
6GKQ
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BU of 6gkq by Molmil
X-ray structure determined from ex vivo Charcot-Leyden crystal
分子名称: GLYCEROL, Galectin-10
著者Verstraete, K, Verschueren, K, Savvides, S.N.
登録日2018-05-21
公開日2019-06-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
4NN6
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BU of 4nn6 by Molmil
Cytokine receptor complex - Crystal form 1B
分子名称: Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, Thymic stromal lymphopoietin
著者Verstraete, K, van Schie, L, Savvides, S.N.
登録日2013-11-16
公開日2014-03-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.545 Å)
主引用文献Structural basis of the proinflammatory signaling complex mediated by TSLP.
Nat.Struct.Mol.Biol., 21, 2014

 

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