6QFB

Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP

Summary for 6QFB

Entry DOI	10.2210/pdb6qfb/pdb
Related	6hxh
Descriptor	ATP-citrate synthase, DIHYDROGENPHOSPHATE ION, COENZYME A, ... (6 entities in total)
Functional Keywords	atp citrate lyase, central metabolism, acetyl-coa, citrate shuttle, rtca cycle, citryl-coa, lipogenesis, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	468902.56
Authors	Verstraete, K.,Verschueren, K. (deposition date: 2019-01-09, release date: 2019-04-10, Last modification date: 2024-01-24)
Primary citation	Verschueren, K.H.G.,Blanchet, C.,Felix, J.,Dansercoer, A.,De Vos, D.,Bloch, Y.,Van Beeumen, J.,Svergun, D.,Gutsche, I.,Savvides, S.N.,Verstraete, K. Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568:571-575, 2019 Cited by PubMed: 30944476 DOI: 10.1038/s41586-019-1095-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation