6HXH
Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP
Summary for 6HXH
Entry DOI | 10.2210/pdb6hxh/pdb |
Descriptor | ATP-citrate synthase,Human ATP citrate lyase, MAGNESIUM ION, PHOSPHATE ION, ... (7 entities in total) |
Functional Keywords | atp citrate lyase, central metabolism, acetyl-coa, citrate shuttle, rtca cycle, citryl-coa, lipogenesis, lyase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 939263.39 |
Authors | Verstraete, K.,Verschueren, K. (deposition date: 2018-10-17, release date: 2019-04-10, Last modification date: 2024-01-24) |
Primary citation | Verschueren, K.H.G.,Blanchet, C.,Felix, J.,Dansercoer, A.,De Vos, D.,Bloch, Y.,Van Beeumen, J.,Svergun, D.,Gutsche, I.,Savvides, S.N.,Verstraete, K. Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568:571-575, 2019 Cited by PubMed: 30944476DOI: 10.1038/s41586-019-1095-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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