6QFB
Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-citrate synthase | polymer | 1050 | 115880.5 | 4 | UniProt (P53396) Pfam (PF16114) Pfam (PF02629) Pfam (PF00549) Pfam (PF00285) | Homo sapiens (Human) | ATP-citrate (pro-S-)-lyase,ACL,Citrate cleavage enzyme |
| 2 | E, I, R (A, B, D) | DIHYDROGENPHOSPHATE ION | non-polymer | 97.0 | 3 | Chemie (2HP) | |||
| 3 | F, K, O, S (A, B, C, D) | COENZYME A | non-polymer | 767.5 | 4 | Chemie (COA) | |||
| 4 | G, L, P, T (A, B, C, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 5 | H, M, N, Q, U (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 6 | J (B) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) |
Sequence modifications
A, B, C, D: 1 - 1101 (UniProt: P53396)
| PDB | External Database | Details |
|---|---|---|
| - | Asn 426 | deletion |
| - | Gln 427 | deletion |
| - | Pro 428 | deletion |
| - | Pro 429 | deletion |
| - | Thr 430 | deletion |
| - | Ala 431 | deletion |
| - | Ala 432 | deletion |
| - | His 433 | deletion |
| - | Thr 434 | deletion |
| - | Ala 435 | deletion |
| - | Asn 436 | deletion |
| - | Phe 437 | deletion |
| - | Leu 438 | deletion |
| - | Leu 439 | deletion |
| - | Asn 440 | deletion |
| - | Ala 441 | deletion |
| - | Ser 442 | deletion |
| - | Gly 443 | deletion |
| - | Ser 444 | deletion |
| - | Thr 445 | deletion |
| - | Ser 446 | deletion |
| - | Thr 447 | deletion |
| - | Pro 448 | deletion |
| - | Ala 449 | deletion |
| - | Pro 450 | deletion |
| - | Ser 451 | deletion |
| - | Arg 452 | deletion |
| - | Thr 453 | deletion |
| - | Ala 454 | deletion |
| - | Ser 455 | deletion |
| - | Phe 456 | deletion |
| - | Ser 457 | deletion |
| - | Glu 458 | deletion |
| - | Ser 459 | deletion |
| - | Arg 460 | deletion |
| - | Ala 461 | deletion |
| - | Asp 462 | deletion |
| - | Glu 463 | deletion |
| - | Val 464 | deletion |
| - | Ala 465 | deletion |
| - | Pro 466 | deletion |
| - | Ala 467 | deletion |
| - | Lys 468 | deletion |
| - | Lys 469 | deletion |
| - | Ala 470 | deletion |
| - | Lys 471 | deletion |
| - | Pro 472 | deletion |
| - | Ala 473 | deletion |
| - | Met 474 | deletion |
| - | Pro 475 | deletion |
| Met 486 | Gln 476 | conflict |
| Gly 1102 | - | expression tag |
| Gly 1103 | - | expression tag |
| Ser 1104 | - | expression tag |
| His 1105 | - | expression tag |
| His 1106 | - | expression tag |
| His 1107 | - | expression tag |
| His 1108 | - | expression tag |
| His 1109 | - | expression tag |
| His 1110 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 463522.0 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 5380.5 | |
| All* | Total formula weight | 468902.6 |
