8AV2

Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80

Summary for 8AV2

Entry DOI	10.2210/pdb8av2/pdb
Related	7Z3R
Descriptor	Leptin receptor, anti-mLEPR VHH 4-80, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	leptin, lep-r, obesity, metabolism, energy balance, cytokine
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	4
Total formula weight	78570.09
Authors	Verstraete, K.,Savvides, S.N.,Verschueren, K.G.,Tsirigotaki, A. (deposition date: 2022-08-26, release date: 2023-04-05, Last modification date: 2024-02-07)
Primary citation	Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K. Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30:551-563, 2023 Cited by PubMed: 36959263 DOI: 10.1038/s41594-023-00941-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation