8AV2
Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Leptin receptor | polymer | 198 | 22779.2 | 2 | UniProt (P48356) | Mus musculus (house mouse) | LEP-R,B219,OB receptor,OB-R |
| 2 | C, D (C, D) | anti-mLEPR VHH 4-80 | polymer | 141 | 15583.2 | 2 | Lama glama | ||
| 3 | E, F, L, M (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 4 | G, H, I, J, K... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 5 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 514 | Chemie (HOH) |
Sequence modifications
A, B: 633 - 827 (UniProt: P48356)
| PDB | External Database | Details |
|---|---|---|
| Glu 630 | - | expression tag |
| Thr 631 | - | expression tag |
| Gly 632 | - | expression tag |
| Gln 668 | Asn 668 | engineered mutation |
| Ser 672 | Cys 672 | conflict |
| Gln 698 | Asn 698 | engineered mutation |
| Gln 726 | Asn 726 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 76724.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1845.5 | |
| All* | Total formula weight | 78570.1 |
