5J13

Structural basis for TSLP antagonism by the therapeutic antibody Tezepelumab (MEDI9929 / AMG-157)

Summary for 5J13

Entry DOI	10.2210/pdb5j13/pdb
Descriptor	Thymic stromal lymphopoietin, anti-TSLP Fab-fragment, light chain, anti-TSLP Fab-fragment, heavy chain, ... (5 entities in total)
Functional Keywords	cytokine inflammation tslp antibody, immune system
Biological source	Homo sapiens (Human) More
Cellular location	Secreted : Q969D9
Total number of polymer chains	3
Total formula weight	71121.21
Authors	Verstraete, K.,Savvides, S.N. (deposition date: 2016-03-28, release date: 2017-04-05, Last modification date: 2024-01-10)
Primary citation	Verstraete, K.,Peelman, F.,Braun, H.,Lopez, J.,Van Rompaey, D.,Dansercoer, A.,Vandenberghe, I.,Pauwels, K.,Tavernier, J.,Lambrecht, B.N.,Hammad, H.,De Winter, H.,Beyaert, R.,Lippens, G.,Savvides, S.N. Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma. Nat Commun, 8:14937-14937, 2017 Cited by PubMed: 28368013 DOI: 10.1038/ncomms14937 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.298 Å)

Structure validation