5J13
Structural basis for TSLP antagonism by the therapeutic antibody Tezepelumab (MEDI9929 / AMG-157)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thymic stromal lymphopoietin | polymer | 147 | 16523.9 | 1 | UniProt (Q969D9) Pfam (PF15216) | Homo sapiens (Human) | |
| 2 | B (B) | anti-TSLP Fab-fragment, light chain | polymer | 245 | 25870.9 | 1 | Homo sapiens (Human) | ||
| 3 | C (C) | anti-TSLP Fab-fragment, heavy chain | polymer | 263 | 28438.2 | 1 | Homo sapiens (Human) | ||
| 4 | D, E, F (B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | G, H, I (A, B, C) | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A: 29 - 159 (UniProt: Q969D9)
| PDB | External Database | Details |
|---|---|---|
| Met 8 | - | initiating methionine |
| Gly 9 | - | expression tag |
| Ser 10 | - | expression tag |
| Ser 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Ser 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Leu 21 | - | expression tag |
| Val 22 | - | expression tag |
| Pro 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Ser 26 | - | expression tag |
| His 27 | - | expression tag |
| Met 28 | - | expression tag |
| - | Lys 126 | deletion |
| - | Arg 127 | deletion |
| - | Arg 128 | deletion |
| - | Lys 129 | deletion |
| - | Arg 130 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70833.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 288.2 | |
| All* | Total formula weight | 71121.2 |
