3QS9

Crystal structure of a human Flt3 ligand-receptor ternary complex

Summary for 3QS9

• Entry DOI: 10.2210/pdb3qs9/pdb
• Related: 3QS7
• Descriptor: SL cytokine, FL cytokine receptor (2 entities in total)
• Functional Keywords: immunoglobulin-like domain, four-helical bundle cytokine, hematopoietic cytokine-receptor complex, cell surface, extracellular complex, receptor tyrosine kinase, cytokine-signaling protein complex, cytokine/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P49771; Membrane; Single-pass type I membrane protein: P36888
• Total number of polymer chains: 8
• Total formula weight: 301629.42

Authors

Verstraete, K.,Savvides, S.N. (deposition date: 2011-02-20, release date: 2011-03-16, Last modification date: 2023-09-13)

• Primary citation: Verstraete, K.,Vandriessche, G.,Januar, M.,Elegheert, J.,Shkumatov, A.V.,Desfosses, A.,Van Craenenbroeck, K.,Svergun, D.I.,Gutsche, I.,Vergauwen, B.,Savvides, S.N.; Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.; Blood, 118:60-68, 2011; PubMed: 21389326; DOI: 10.1182/blood-2011-01-329532

Experimental method

X-RAY DIFFRACTION (7.8 Å)