3QS9

Crystal structure of a human Flt3 ligand-receptor ternary complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	SL cytokine	polymer	138	15873.2	4	UniProt (P49771) Pfam (PF02947)	Homo sapiens (human)	Flt3 ligand, Fms-related tyrosine kinase 3 ligand, Flt3L
2	E, F, G, H (E, F, G, H)	FL cytokine receptor	polymer	527	59534.1	4	UniProt (P36888) Pfam (PF00047)	Homo sapiens (human)	Tyrosine-protein kinase receptor FLT3, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1

Sequence modifications

A, B, C, D: 1 - 134 (UniProt: P49771)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

E, F, G, H: 27 - 540 (UniProt: P36888)

PDB	External Database	Details
Glu 24	-	expression tag
Thr 25	-	expression tag
Gly 26	-	expression tag
Gly 541	-	expression tag
Gly 542	-	expression tag
Thr 543	-	expression tag
Lys 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	301629.4
All*	Total formula weight	301629.4

*Water molecules are not included.