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PDB: 37 件
3ZFK
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BU of 3zfk by Molmil
N-terminal truncated Nuclease Domain of Colicin E7
分子名称: ACETATE ION, CHLORIDE ION, COLICIN-E7, ...
著者Toth, E, Czene, A, Gyurcsik, B, Otten, H, Poulsen, J.-C.N, Larsen, S, Christensen, H.E.M, Nagata, K.
登録日2012-12-11
公開日2013-12-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A New Insight Into the Zinc-Dependent DNA-Cleavage by the Colicin E7 Nuclease: A Crystallographic and Computational Study.
Metallomics, 6, 2014
1Q57
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BU of 1q57 by Molmil
The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7
分子名称: DNA primase/helicase
著者Toth, E.A, Li, Y, Sawaya, M.R, Cheng, Y, Ellenberger, T.
登録日2003-08-06
公開日2003-11-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7
Mol.Cell, 12, 2003
1F1O
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BU of 1f1o by Molmil
STRUCTURAL STUDIES OF ADENYLOSUCCINATE LYASES
分子名称: ADENYLOSUCCINATE LYASE
著者Toth, E.A, Yeates, T.
登録日2000-05-19
公開日2001-01-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
J.Mol.Biol., 301, 2000
6UAI
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BU of 6uai by Molmil
Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with YSAM peptide
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Toth, E.A, Bryan, P.N, Orban, J.
登録日2019-09-10
公開日2020-09-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Engineering subtilisin proteases that specifically degrade active RAS.
Commun Biol, 4, 2021
6UAO
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BU of 6uao by Molmil
Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with the peptide EEYSAM
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Peptide EEYSAM, ...
著者Toth, E.A, Bryan, P.N, Orban, J.
登録日2019-09-11
公開日2020-09-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Engineering subtilisin proteases that specifically degrade active RAS.
Commun Biol, 4, 2021
6UBE
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BU of 6ube by Molmil
Azide-triggered subtilisin SUBT_BACAM complexed with the peptide LFRAL
分子名称: AZIDE ION, GLYCEROL, Peptide LFRAL, ...
著者Toth, E.A, Bryan, P.N, Orban, J, Gallagher, D.T, Custer, G.
登録日2019-09-11
公開日2020-09-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Engineering subtilisin proteases that specifically degrade active RAS.
Commun Biol, 4, 2021
6U9L
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BU of 6u9l by Molmil
Imidazole-triggered RAS-specific subtilisin SUBT_BACAM
分子名称: GLYCEROL, POTASSIUM ION, SUBTILISIN BPN', ...
著者Toth, E.A, Bryan, P.N, Orban, J.
登録日2019-09-09
公開日2020-09-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Engineering subtilisin proteases that specifically degrade active RAS.
Commun Biol, 4, 2021
1DOF
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BU of 1dof by Molmil
THE CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM PYROBACULUM AEROPHILUM: INSIGHTS INTO THERMAL STABILITY AND HUMAN PATHOLOGY
分子名称: ADENYLOSUCCINATE LYASE
著者Toth, E.A, Yeates, T.O, Goedken, E, Dixon, J.E, Marqusee, S.
登録日1999-12-20
公開日2001-01-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
J.Mol.Biol., 301, 2000
3N5N
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BU of 3n5n by Molmil
Crystal structure analysis of the catalytic domain and interdomain connector of human MutY homologue
分子名称: A/G-specific adenine DNA glycosylase, ACETATE ION, IRON/SULFUR CLUSTER
著者Toth, E.A, Luncsford, P.J.
登録日2010-05-25
公開日2010-11-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A structural hinge in eukaryotic MutY homologues mediates catalytic activity and Rad9-Rad1-Hus1 checkpoint complex interactions.
J.Mol.Biol., 403, 2010
1C3U
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BU of 1c3u by Molmil
T. MARITIMA ADENYLOSUCCINATE LYASE
分子名称: ADENYLOSUCCINATE LYASE, SULFATE ION
著者Toth, E.A, Yeates, T.O.
登録日1999-07-28
公開日2000-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway.
Structure Fold.Des., 8, 2000
1C3C
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BU of 1c3c by Molmil
T. MARITIMA ADENYLOSUCCINATE LYASE
分子名称: PROTEIN (ADENYLOSUCCINATE LYASE)
著者Toth, E.A, Yeates, T.O.
登録日1999-07-27
公開日2000-02-09
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway.
Structure Fold.Des., 8, 2000
1K1Q
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BU of 1k1q by Molmil
Crystal Structure of a DinB Family Error Prone DNA Polymerase from Sulfolobus solfataricus
分子名称: DBH protein
著者Silvian, L.F, Toth, E.A, Pham, P, Goodman, M.F, Ellenberger, T.
登録日2001-09-25
公開日2001-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.
Nat.Struct.Biol., 8, 2001
1K1S
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BU of 1k1s by Molmil
Crystal Structure of DinB from Sulfolobus solfataricus
分子名称: DBH protein
著者Silvian, L.F, Toth, E.A, Pham, P, Goodman, M.F, Ellenberger, T.
登録日2001-09-25
公開日2001-10-31
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.
Nat.Struct.Biol., 8, 2001
5EAI
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BU of 5eai by Molmil
Crystal Structure of NAD(P)H dehydrogenase, quinone 1 complexed with a chemotherapeutic naphthoquinone E6a
分子名称: (2~{R},3~{R})-2-[(2~{S},3~{S})-3-bromanyl-1,4-bis(oxidanylidene)-2,3-dihydronaphthalen-2-yl]-3-oxidanyl-2,3-dihydronaphthalene-1,4-dione, FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H dehydrogenase [quinone] 1
著者Pidugu, L.S, Mbimba, J.E, Ahmad, M, Pozharski, E, Sausville, E.A, Emadi, A, Toth, E.A.
登録日2015-10-16
公開日2016-02-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.
Bmc Struct.Biol., 16, 2016
5EA2
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BU of 5ea2 by Molmil
Crystal Structure of Holo NAD(P)H dehydrogenase, quinone 1
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H dehydrogenase [quinone] 1
著者Pidugu, L.S, Mbimba, J.E, Ahmad, M, Pozharski, E, Sausville, E.A, Emadi, A, Toth, E.A.
登録日2015-10-15
公開日2016-02-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.
Bmc Struct.Biol., 16, 2016
5DKN
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BU of 5dkn by Molmil
Crystal Structure of Calcium-loaded S100B bound to SBi4225
分子名称: 2,2'-[heptane-1,7-diylbis(oxybenzene-4,1-diyl)]bis(1H-imidazole), CALCIUM ION, Protein S100-B
著者Cavalier, M.C, Ansari, M.I, Pierce, A.D, Wilder, P.T, McKnight, L.E, Raman, E.P, Neau, D.B, Bezawada, P, Alasady, M.J, Varney, K.M, Toth, E.A, MacKerell Jr, A.D, Coop, A, Weber, D.J.
登録日2015-09-03
公開日2016-01-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.528 Å)
主引用文献Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
J.Med.Chem., 59, 2016
4DIR
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BU of 4dir by Molmil
2.6 Angstrom X-ray structure of human CA(2+)-S100A5
分子名称: CALCIUM ION, Protein S100-A5
著者Liriano, M.A, Toth, E.A, Weber, D.J.
登録日2012-01-31
公開日2013-02-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Target-binding to S100A5 changes Ca(2+)-binding affinity and dynamics.
To be Published
5DKR
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BU of 5dkr by Molmil
Crystal Structure of Calcium-loaded S100B bound to SBi29
分子名称: 2-[4-(4-carbamimidoylphenoxy)phenyl]-1H-indole-6-carboximidamide, CALCIUM ION, Protein S100-B
著者Cavalier, M.C, Ansari, M.I, Pierce, A.D, Wilder, P.T, McKnight, L.E, Raman, E.P, Neau, D.B, Bezawada, P, Alasady, M.J, Varney, K.M, Toth, E.A, MacKerell Jr, A.D, Coop, A, Weber, D.J.
登録日2015-09-03
公開日2016-01-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.742 Å)
主引用文献Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
J.Med.Chem., 59, 2016
4LND
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BU of 4lnd by Molmil
Crystal structure of human apurinic/apyrimidinic endonuclease 1 with essential Mg2+ cofactor
分子名称: DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION
著者Manvilla, B.A, Pozharski, E, Toth, E.A, Drohat, A.C.
登録日2013-07-11
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg(2+) cofactor.
Acta Crystallogr.,Sect.D, 69, 2013
5DKQ
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BU of 5dkq by Molmil
Crystal Structure of Calcium-loaded S100B bound to SBi4214
分子名称: 2,2'-[pentane-1,5-diylbis(oxybenzene-4,1-diyl)]di-1,4,5,6-tetrahydropyrimidine, CALCIUM ION, Protein S100-B
著者Cavalier, M.C, Ansari, M.I, Pierce, A.D, Wilder, P.T, McKnight, L.E, Raman, E.P, Neau, D.B, Bezawada, P, Alasady, M.J, Varney, K.M, Toth, E.A, MacKerell Jr, A.D, Coop, A, Weber, D.J.
登録日2015-09-03
公開日2016-01-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.591 Å)
主引用文献Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
J.Med.Chem., 59, 2016
4KWW
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BU of 4kww by Molmil
The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid
分子名称: Nicotinate-nucleotide pyrophosphorylase [carboxylating], PHTHALIC ACID
著者Malik, S.S, Dimeka, P.N, Ncube, Z, Toth, E.A.
登録日2013-05-24
公開日2013-10-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid.
Proteins, 82, 2014
4KWV
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BU of 4kwv by Molmil
Crystal Structure of human apo-QPRT
分子名称: Nicotinate-nucleotide pyrophosphorylase [carboxylating]
著者Malik, S.S, Patterson, D.N, Ncube, Z, Toth, E.A.
登録日2013-05-24
公開日2013-10-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.797 Å)
主引用文献The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid.
Proteins, 82, 2014
5TKQ
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Crystal structure of human 3HAO with zinc bound in the active site
分子名称: 3-hydroxyanthranilate 3,4-dioxygenase, SULFATE ION, ZINC ION
著者Pidugu, L.S, Toth, E.A.
登録日2016-10-07
公開日2017-04-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structures of human 3-hydroxyanthranilate 3,4-dioxygenase with native and non-native metals bound in the active site.
Acta Crystallogr D Struct Biol, 73, 2017
5TK5
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BU of 5tk5 by Molmil
Crystal structure of human 3HAO with iron bound in the active site
分子名称: 3-hydroxyanthranilate 3,4-dioxygenase, FE (III) ION, SULFATE ION
著者Pidugu, L.S, Toth, E.A.
登録日2016-10-06
公開日2017-04-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Crystal structures of human 3-hydroxyanthranilate 3,4-dioxygenase with native and non-native metals bound in the active site.
Acta Crystallogr D Struct Biol, 73, 2017
4FQO
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Crystal Structure of Calcium-Loaded S100B Bound to SBi4211
分子名称: 4,4'-[heptane-1,7-diylbis(oxy)]dibenzenecarboximidamide, CALCIUM ION, Protein S100-B
著者McKnight, L.E, Raman, E.P, Bezawada, P, Kudrimoti, S, Wilder, P.T, Hartman, K.G, Toth, E.A, Coop, A, MacKerrell, A.D, Weber, D.J.
登録日2012-06-25
公開日2012-10-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B.
ACS Med Chem Lett, 3, 2012

 

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