6UAI

Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with YSAM peptide

Summary for 6UAI

• Entry DOI: 10.2210/pdb6uai/pdb
• Related: 6U9L
• Descriptor: SUBTILISIN BPN', YSAM peptide, SODIUM ION, ... (7 entities in total)
• Functional Keywords: engineered protease, hydrolase
• Biological source: Bacillus amyloliquefaciens; More
• Total number of polymer chains: 2
• Total formula weight: 27362.88

Authors

Toth, E.A.,Bryan, P.N.,Orban, J. (deposition date: 2019-09-10, release date: 2020-09-16, Last modification date: 2023-10-11)

• Primary citation: Chen, Y.,Toth, E.A.,Ruan, B.,Choi, E.J.,Simmerman, R.,Chen, Y.,He, Y.,Wang, R.,Godoy-Ruiz, R.,King, H.,Custer, G.,Travis Gallagher, D.,Rozak, D.A.,Solomon, M.,Muro, S.,Weber, D.J.,Orban, J.,Fuerst, T.R.,Bryan, P.N.; Engineering subtilisin proteases that specifically degrade active RAS.; Commun Biol, 4:299-299, 2021; PubMed: 33674772; DOI: 10.1038/s42003-021-01818-7

Experimental method

X-RAY DIFFRACTION (1.2 Å)