3N5N

Crystal structure analysis of the catalytic domain and interdomain connector of human MutY homologue

Summary for 3N5N

Entry DOI	10.2210/pdb3n5n/pdb
Descriptor	A/G-specific adenine DNA glycosylase, IRON/SULFUR CLUSTER, ACETATE ION, ... (4 entities in total)
Functional Keywords	alpha-helices, helix-hairpin-helix motif, iron-sulfur cluster, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q9UIF7
Total number of polymer chains	2
Total formula weight	64271.96
Authors	Toth, E.A.,Luncsford, P.J. (deposition date: 2010-05-25, release date: 2010-11-10, Last modification date: 2023-09-06)
Primary citation	Luncsford, P.J.,Chang, D.Y.,Shi, G.,Bernstein, J.,Madabushi, A.,Patterson, D.N.,Lu, A.L.,Toth, E.A. A structural hinge in eukaryotic MutY homologues mediates catalytic activity and Rad9-Rad1-Hus1 checkpoint complex interactions. J.Mol.Biol., 403:351-370, 2010 Cited by PubMed: 20816984 DOI: 10.1016/j.jmb.2010.08.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation