5EAI
Crystal Structure of NAD(P)H dehydrogenase, quinone 1 complexed with a chemotherapeutic naphthoquinone E6a
Summary for 5EAI
Entry DOI | 10.2210/pdb5eai/pdb |
Related | 5EA2 |
Descriptor | NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, (2~{R},3~{R})-2-[(2~{S},3~{S})-3-bromanyl-1,4-bis(oxidanylidene)-2,3-dihydronaphthalen-2-yl]-3-oxidanyl-2,3-dihydronaphthalene-1,4-dione, ... (4 entities in total) |
Functional Keywords | nqo1, two-electron reduction of quinone, nad(p)h dehydrogenase, dimeric naphthoquinone, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P15559 |
Total number of polymer chains | 14 |
Total formula weight | 449862.70 |
Authors | Pidugu, L.S.,Mbimba, J.E.,Ahmad, M.,Pozharski, E.,Sausville, E.A.,Emadi, A.,Toth, E.A. (deposition date: 2015-10-16, release date: 2016-02-17, Last modification date: 2024-03-06) |
Primary citation | Pidugu, L.S.,Mbimba, J.C.,Ahmad, M.,Pozharski, E.,Sausville, E.A.,Emadi, A.,Toth, E.A. A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone. Bmc Struct.Biol., 16:1-1, 2016 Cited by PubMed: 26822308DOI: 10.1186/s12900-016-0052-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report