5EAI

Crystal Structure of NAD(P)H dehydrogenase, quinone 1 complexed with a chemotherapeutic naphthoquinone E6a

Summary for 5EAI

• Entry DOI: 10.2210/pdb5eai/pdb
• Related: 5EA2
• Descriptor: NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, (2~{R},3~{R})-2-[(2~{S},3~{S})-3-bromanyl-1,4-bis(oxidanylidene)-2,3-dihydronaphthalen-2-yl]-3-oxidanyl-2,3-dihydronaphthalene-1,4-dione, ... (4 entities in total)
• Functional Keywords: nqo1, two-electron reduction of quinone, nad(p)h dehydrogenase, dimeric naphthoquinone, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P15559
• Total number of polymer chains: 14
• Total formula weight: 449862.70

Authors

Pidugu, L.S.,Mbimba, J.E.,Ahmad, M.,Pozharski, E.,Sausville, E.A.,Emadi, A.,Toth, E.A. (deposition date: 2015-10-16, release date: 2016-02-17, Last modification date: 2024-03-06)

• Primary citation: Pidugu, L.S.,Mbimba, J.C.,Ahmad, M.,Pozharski, E.,Sausville, E.A.,Emadi, A.,Toth, E.A.; A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.; Bmc Struct.Biol., 16:1-1, 2016; PubMed: 26822308; DOI: 10.1186/s12900-016-0052-x

Experimental method

X-RAY DIFFRACTION (2.9 Å)