5EAI
Crystal Structure of NAD(P)H dehydrogenase, quinone 1 complexed with a chemotherapeutic naphthoquinone E6a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | NAD(P)H dehydrogenase [quinone] 1 | polymer | 277 | 31199.9 | 14 | UniProt (P15559) Pfam (PF02525) | Homo sapiens (Human) | Azoreductase,DT-diaphorase,DTD,Menadione reductase,NAD(P)H:quinone oxidoreductase 1,Phylloquinone reductase,Quinone reductase 1,QR1 |
| 2 | AA, BA, DA, EA, GA... (J, K, L, M, N...) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 14 | Chemie (FAD) | |||
| 3 | CA, FA, Q, U, Y (K, M, B, E, H) | (2~{R},3~{R})-2-[(2~{S},3~{S})-3-bromanyl-1,4-bis(oxidanylidene)-2,3-dihydronaphthalen-2-yl]-3-oxidanyl-2,3-dihydronaphthalene-1,4-dione | non-polymer | 413.2 | 5 | Chemie (E6A) PubChem (117587706) | |||
| 4 | HA, IA, JA, KA, LA... (A, B, C, D, E...) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N: 0 - 273 (UniProt: P15559)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 436798.9 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 13063.8 | |
| All* | Total formula weight | 449862.7 |
