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PDB: 209 件
3BEN
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BU of 3ben by Molmil
Structure of N-(12-imidazolyl-dodecanoyl)-L-leucine inhibitor bound to the heme domain of Cytochrome P450-BM3
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cytochrome P450 102, MAGNESIUM ION, ...
著者Tomchick, D.R.
登録日2007-11-19
公開日2008-09-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel.
Biochemistry, 47, 2008
3L15
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BU of 3l15 by Molmil
Human Tead2 transcriptional factor
分子名称: GLYCEROL, Transcriptional enhancer factor TEF-4
著者Tomchick, D.R, Luo, X, Tian, W.
登録日2009-12-10
公開日2010-04-07
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional analysis of the YAP-binding domain of human TEAD2.
Proc.Natl.Acad.Sci.USA, 107, 2010
8DML
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BU of 8dml by Molmil
Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt chenodeoxycholate
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHENODEOXYCHOLIC ACID, ...
著者Tomchick, D.R, Orth, K, Zou, A.J.
登録日2022-07-08
公開日2023-06-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus.
J.Biol.Chem., 299, 2023
7M7A
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BU of 7m7a by Molmil
Legionella pneumophila MavQ lipid kinase
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoinositide 3-kinase MavQ
著者Tomchick, D.R, Tagliabracci, V.S, Hsieh, T.S, Lopez, V.A.
登録日2021-03-27
公開日2021-04-28
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Dynamic remodeling of host membranes by self-organizing bacterial effectors.
Science, 372, 2021
3BND
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BU of 3bnd by Molmil
Lipoxygenase-1 (Soybean), I553V Mutant
分子名称: FE (III) ION, Seed lipoxygenase-1
著者Tomchick, D.R.
登録日2007-12-14
公開日2008-04-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.
Proc.Natl.Acad.Sci.Usa, 105, 2008
6EAC
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BU of 6eac by Molmil
Pseudomonas syringae SelO
分子名称: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
著者Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A.
登録日2018-08-02
公開日2018-10-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.269 Å)
主引用文献Protein AMPylation by an Evolutionarily Conserved Pseudokinase.
Cell, 175, 2018
9B8D
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BU of 9b8d by Molmil
Structure of Legionella pneumophila Ceg10
分子名称: 1,2-ETHANEDIOL, Ceg10, PHOSPHATE ION
著者Tomchick, D.R, Heisler, D.B, Alto, N.M.
登録日2024-03-29
公開日2024-04-10
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery.
Plos Pathog., 20, 2024
9B8E
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BU of 9b8e by Molmil
Structure of S-nitrosylated Legionella pneumophila Ceg10.
分子名称: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ...
著者Tomchick, D.R, Heisler, D.B, Alto, N.M.
登録日2024-03-29
公開日2024-04-10
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery.
Plos Pathog., 20, 2024
5T8V
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BU of 5t8v by Molmil
Chaetomium thermophilum cohesin loader SCC2, C-terminal fragment
分子名称: CITRIC ACID, Putative uncharacterized protein
著者Tomchick, D.R, Yu, H, Kikuchi, S, Ouyang, Z, Borek, D, Otwinowski, Z.
登録日2016-09-08
公開日2016-10-19
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.798 Å)
主引用文献Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy.
Proc.Natl.Acad.Sci.USA, 113, 2016
6DFT
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BU of 6dft by Molmil
Trypanosoma brucei deoxyhypusine synthase
分子名称: Deoxyhypusine synthase, Deoxyhypusine synthase regulatory subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Tomchick, D.R, Phillips, M.A, Afanador, G.A.
登録日2018-05-15
公開日2018-08-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.
Structure, 26, 2018
6E0B
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BU of 6e0b by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1
分子名称: 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Tomchick, D.R, Phillips, M.A, Deng, X.
登録日2018-07-06
公開日2018-11-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
ACS Infect Dis, 5, 2019
4R8Q
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BU of 4r8q by Molmil
Structure and substrate recruitment of the human spindle checkpoint kinase bub1
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitotic checkpoint serine/threonine-protein kinase BUB1
著者Tomchick, D.R, Yu, H.
登録日2014-09-02
公開日2014-11-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.
Mol.Cell, 32, 2008
4R3A
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BU of 4r3a by Molmil
Erythrobacter litoralis EL346 blue-light activated histidine kinase
分子名称: Blue-light-activated histidine kinase 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Tomchick, D.R, Rivera-Cancel, G, Gardner, K.H.
登録日2014-08-14
公開日2014-12-03
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation.
Proc.Natl.Acad.Sci.USA, 111, 2014
5EW4
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BU of 5ew4 by Molmil
Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+
分子名称: CHLORIDE ION, MAGNESIUM ION, POTASSIUM ION, ...
著者Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R.
登録日2015-11-20
公開日2016-02-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.
Biochemistry, 55, 2016
5EW7
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BU of 5ew7 by Molmil
Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Ba2+
分子名称: BARIUM ION, MAGNESIUM ION, POTASSIUM ION, ...
著者Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R.
登録日2015-11-20
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.
Biochemistry, 55, 2016
6ANJ
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BU of 6anj by Molmil
Synaptotagmin-7, C2A domain
分子名称: ACETATE ION, CALCIUM ION, Synaptotagmin-7, ...
著者Tomchick, D.R, Rizo, J, Voleti, R.
登録日2017-08-13
公開日2017-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6AO5
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BU of 6ao5 by Molmil
Crystal structure of human MST2 in complex with SAV1 SARAH domain
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein salvador homolog 1, ...
著者Tomchick, D.R, Luo, X, Ni, L.
登録日2017-08-15
公開日2017-11-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.955 Å)
主引用文献SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Elife, 6, 2017
6ANK
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BU of 6ank by Molmil
Synaptotagmin-7, C2A- and C2B-domains
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Synaptotagmin-7
著者Tomchick, D.R, Rizo, J, Voleti, R.
登録日2017-08-13
公開日2017-09-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.254 Å)
主引用文献Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5JDA
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BU of 5jda by Molmil
Bacillus cereus CotH kinase plus Mg2+/AMP
分子名称: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ...
著者Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A.
登録日2016-04-15
公開日2016-05-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献Phosphorylation of spore coat proteins by a family of atypical protein kinases.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KEV
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BU of 5kev by Molmil
Vibrio parahaemolyticus VtrA/VtrC complex
分子名称: SULFATE ION, VtrA Protein, VtrC Protein
著者Tomchick, D.R, Orth, K, Rivera-Cancel, G.
登録日2016-06-10
公開日2016-07-20
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Bile salt receptor complex activates a pathogenic type III secretion system.
Elife, 5, 2016
5JD9
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BU of 5jd9 by Molmil
Bacillus cereus CotH kinase
分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Spore coat protein H
著者Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A.
登録日2016-04-15
公開日2016-05-18
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Phosphorylation of spore coat proteins by a family of atypical protein kinases.
Proc.Natl.Acad.Sci.USA, 113, 2016
5UF7
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BU of 5uf7 by Molmil
CRYSTAL STRUCTURE OF MUNC13-1 MUN DOMAIN
分子名称: Protein unc-13 homolog A
著者Tomchick, D.R, Rizo, J, Xu, J.
登録日2017-01-03
公開日2017-02-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.896 Å)
主引用文献Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.
Elife, 6, 2017
8VTT
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BU of 8vtt by Molmil
Meis1 homeobox domain bound to neomycin fragment
分子名称: Homeobox protein Meis1, RIBOSTAMYCIN, SULFATE ION
著者Tomchick, D.R, Ahmed, M.S, Nguyen, N.U.N, Sadek, H.A.
登録日2024-01-27
公開日2024-02-14
最終更新日2024-09-11
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Identification of FDA-approved drugs that induce heart regeneration in mammals.
Nat Cardiovasc Res, 3, 2024
8VTS
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BU of 8vts by Molmil
Meis1 homeobox domain bound to paromomycin fragment
分子名称: 1,2-ETHANEDIOL, Homeobox protein Meis1, ISOPROPYL ALCOHOL, ...
著者Tomchick, D.R, Ahmed, M.S, Nguyen, N.U.N.
登録日2024-01-27
公開日2024-02-14
最終更新日2024-09-11
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Identification of FDA-approved drugs that induce heart regeneration in mammals.
Nat Cardiovasc Res, 3, 2024
4DBB
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BU of 4dbb by Molmil
The PTB domain of Mint1 is autoinhibited by a helix in the C-terminal linker region
分子名称: ACETIC ACID, Amyloid beta A4 precursor protein-binding family A member 1, CHLORIDE ION, ...
著者Tomchick, D.R, Rizo, J, Ho, A, Xu, Y.
登録日2012-01-13
公開日2012-03-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing.
Proc.Natl.Acad.Sci.USA, 109, 2012

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