5EW7
Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Ba2+
Summary for 5EW7
Entry DOI | 10.2210/pdb5ew7/pdb |
Related | 5EW4 |
Descriptor | RNA (5'-R(*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*C)-3'), POTASSIUM ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | repeat expansion disorder, genetic disease, rna |
Biological source | Homo sapiens |
Total number of polymer chains | 2 |
Total formula weight | 14209.31 |
Authors | Tomchick, D.R.,Dodd, D.W.,Gagnon, K.T.,Corey, D.R. (deposition date: 2015-11-20, release date: 2016-02-24, Last modification date: 2023-09-27) |
Primary citation | Dodd, D.W.,Tomchick, D.R.,Corey, D.R.,Gagnon, K.T. Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches. Biochemistry, 55:1283-1286, 2016 Cited by PubMed: 26878348DOI: 10.1021/acs.biochem.6b00136 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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