6E0B
Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1
Summary for 6E0B
Entry DOI | 10.2210/pdb6e0b/pdb |
Related | 3I65 3I68 3I6R |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, FLAVIN MONONUCLEOTIDE, ... (7 entities in total) |
Functional Keywords | plasmodium falciparum, dihydroorotate dehydrogenase, triazolopyrimidine, inhibitor, dsm1, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, pyrimidine biosynthesis, transit peptide |
Biological source | Plasmodium falciparum (isolate 3D7) |
Total number of polymer chains | 1 |
Total formula weight | 46825.39 |
Authors | Tomchick, D.R.,Phillips, M.A.,Deng, X. (deposition date: 2018-07-06, release date: 2018-11-14, Last modification date: 2023-10-11) |
Primary citation | White, J.,Dhingra, S.K.,Deng, X.,El Mazouni, F.,Lee, M.C.S.,Afanador, G.A.,Lawong, A.,Tomchick, D.R.,Ng, C.L.,Bath, J.,Rathod, P.K.,Fidock, D.A.,Phillips, M.A. Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infect Dis, 5:90-101, 2019 Cited by PubMed: 30375858DOI: 10.1021/acsinfecdis.8b00211 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.099 Å) |
Structure validation
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