4R8Q

Structure and substrate recruitment of the human spindle checkpoint kinase bub1

Replaces:  3E7E

Summary for 4R8Q

Related4QPM
DescriptorMitotic checkpoint serine/threonine-protein kinase BUB1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsspindle assembly checkpoint, mitosis, kinase, activation, ken box, cdc20, atp-binding, cell cycle, cell division, disease mutation, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus O43683
Total number of polymer chains1
Total molecular weight42323.39
Authors
Tomchick, D.R.,Yu, H. (deposition date: 2014-09-02, release date: 2014-11-12, Last modification date: 2017-11-22)
Primary citation
Kang, J.,Yang, M.,Li, B.,Qi, W.,Zhang, C.,Shokat, K.M.,Tomchick, D.R.,Machius, M.,Yu, H.
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.
Mol.Cell, 32:394-405, 2008
PubMed: 18995837 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2008.09.017
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.31 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.267100.7%8.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload