4R8Q

Structure and substrate recruitment of the human spindle checkpoint kinase bub1

Replaces:  3E7E

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007094	biological_process	mitotic spindle assembly checkpoint signaling

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP A 1501

Chain	Residue
A	GLY794
A	TYR869
A	THR873
A	ASP921
A	ASN922
A	ASP946
A	MG1502
A	MG1503
A	HOH1601
A	HOH1604
A	HOH1605
A	GLY796
A	ALA797
A	PHE798
A	ALA799
A	VAL801
A	LYS821
A	MET850
A	GLU867

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1502

Chain	Residue
A	ASN922
A	ASP946
A	ADP1501
A	HOH1601
A	HOH1602

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1503

Chain	Residue
A	ASP946
A	ADP1501
A	HOH1603
A	HOH1604
A	HOH1605

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFAQVYeAtqgdlndaknkqk.....FVLK

Chain	Residue	Details
A	LEU793-LYS821

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHgDIKpdNFIL

Chain	Residue	Details
A	ILE913-LEU925

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---