5EW4

Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+

Summary for 5EW4

• Entry DOI: 10.2210/pdb5ew4/pdb
• Related: 5EW7
• Descriptor: RNA (5'-R(*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*C)-3'), POTASSIUM ION, STRONTIUM ION, ... (6 entities in total)
• Functional Keywords: repeat expansion disorder, genetic disease, rna
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 14341.94

Authors

Tomchick, D.R.,Dodd, D.W.,Gagnon, K.T.,Corey, D.R. (deposition date: 2015-11-20, release date: 2016-02-24, Last modification date: 2024-03-06)

• Primary citation: Dodd, D.W.,Tomchick, D.R.,Corey, D.R.,Gagnon, K.T.; Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.; Biochemistry, 55:1283-1286, 2016; PubMed: 26878348; DOI: 10.1021/acs.biochem.6b00136

Experimental method

X-RAY DIFFRACTION (1.47 Å)