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PDB: 60 件
3CWW
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BU of 3cww by Molmil
Crystal Structure of IDE-bradykinin complex
分子名称: 1,4-DIETHYLENE DIOXIDE, ACETATE ION, Insulin-degrading enzyme, ...
著者Malito, E, Tang, W.J.
登録日2008-04-23
公開日2008-11-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme
Biochemistry, 47, 2008
5WOB
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BU of 5wob by Molmil
Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
分子名称: IDE-bound Fab heavy chain, IDE-bound Fab light chain, Insulin, ...
著者McCord, L.A, Liang, W.G, Farcasanu, M, Wang, A.G, Koide, S, Tang, W.J.
登録日2017-08-01
公開日2018-04-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.95 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
4GS8
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BU of 4gs8 by Molmil
Structure analysis of cysteine free insulin degrading enzyme (ide) with compound bdm43079 [{[(s)-2-(1h-imidazol-4-yl)-1-methylcarbamoyl-ethylcarbamoyl]-methyl}-(3-phenyl-propyl)-amino]-acetic acid
分子名称: Insulin-degrading enzyme, N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-N-methyl-L-histidinamide, ZINC ION
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GSC
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BU of 4gsc by Molmil
Structure analysis of insulin degrading enzyme with compound bdm41559 ((s)-2-[2-(carboxymethyl-phenethyl-amino)-acetylamino]-3-(1h-imidazol-4-yl)-propionic acid methyl ester)
分子名称: Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(2-phenylethyl)glycyl-L-histidinate
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
7RZI
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BU of 7rzi by Molmil
Insulin Degrading Enzyme pC/pC
分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZH
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BU of 7rzh by Molmil
Insulin Degrading Enzyme O/O
分子名称: Cysteine-free Insulin-degrading enzyme
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZE
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Insulin Degrading Enzyme pO/pC
分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZF
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BU of 7rzf by Molmil
Insulin Degrading Enzyme O/pC
分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZG
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BU of 7rzg by Molmil
Insulin Degrading Enzyme O/pO
分子名称: Cysteine-free Insulin-degrading enzyme
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
3CQF
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BU of 3cqf by Molmil
Crystal structure of anthrolysin O (ALO)
分子名称: Thiol-activated cytolysin
著者Bourdeau, R.W, Malito, E, Tang, W.J.
登録日2008-04-02
公開日2009-03-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis
J.Biol.Chem., 284, 2009
1PK0
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BU of 1pk0 by Molmil
Crystal Structure of the EF3-CaM complexed with PMEApp
分子名称: (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ...
著者Shen, Y, Tang, W.J.
登録日2003-06-04
公開日2004-02-10
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Proc.Natl.Acad.Sci.USA, 101, 2004
2WC0
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BU of 2wc0 by Molmil
crystal structure of human insulin degrading enzyme in complex with iodinated insulin
分子名称: 1,4-DIETHYLENE DIOXIDE, INSULIN A CHAIN, INSULIN B CHAIN, ...
著者Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J.
登録日2009-03-06
公開日2009-03-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2WK3
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BU of 2wk3 by Molmil
Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42)
分子名称: BETA-AMYLOID PROTEIN 42, INSULIN DEGRADING ENZYME, ZINC ION
著者Guo, Q, Tang, W.J.
登録日2009-06-05
公開日2009-11-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Molecular Basis for the Recognition and Cleavages of Igf-II, Tgf-Alpha, and Amylin by Human Insulin Degrading Enzyme.
J.Mol.Biol., 395, 2010
2WBY
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BU of 2wby by Molmil
Crystal structure of human insulin-degrading enzyme in complex with insulin
分子名称: INSULIN A CHAIN, INSULIN B CHAIN, INSULIN-DEGRADING ENZYME, ...
著者Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J.
登録日2009-03-06
公開日2009-03-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2COL
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BU of 2col by Molmil
Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
分子名称: Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin, ...
著者Guo, Q, Tang, W.J, Shen, Y.
登録日2005-05-18
公開日2006-01-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
Embo J., 24, 2005
5UOE
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BU of 5uoe by Molmil
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
分子名称: FAB Heavy chain with engineered elbow, FAB light chain, Insulin-degrading enzyme
著者Liang, W.G, Bailey, L, Kossiakoff, T, Tang, W.J.
登録日2017-01-31
公開日2018-02-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
To Be Published
3E4A
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BU of 3e4a by Molmil
Human IDE-inhibitor complex at 2.6 angstrom resolution
分子名称: 1,4-DIETHYLENE DIOXIDE, ACETIC ACID, HYDROXAMATE PEPTIDE II1, ...
著者Malito, E, Leissring, M.A, Choi, S, Cuny, G.D, Tang, W.J.
登録日2008-08-11
公開日2009-05-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Plos One, 5, 2010
3H44
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BU of 3h44 by Molmil
Crystal Structure of Insulin Degrading Enzyme in Complex with macrophage inflammatory protein 1 alpha
分子名称: 1,4-DIETHYLENE DIOXIDE, C-C motif chemokine 3, Insulin-degrading enzyme, ...
著者Ren, M, Guo, Q, Tang, W.J.
登録日2009-04-17
公開日2010-04-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Macrophage Inflammatory Protein-1 Is A Novel High Affinity Substrate For Human Insulin Degrading Enzyme
To be Published
3HGZ
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BU of 3hgz by Molmil
Crystal structure of human insulin-degrading enzyme in complex with amylin
分子名称: Insulin-degrading enzyme, Islet amyloid polypeptide, ZINC ION
著者Guo, Q, Bian, Y, Tang, W.J.
登録日2009-05-14
公開日2009-12-08
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
4IOF
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BU of 4iof by Molmil
Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE)
分子名称: Fab-bound IDE, heavy chain, light chain, ...
著者McCord, L.A, Liang, W.G, Hoey, R, Dowdell, E, Koide, A, Koide, S, Tang, W.J.
登録日2013-01-07
公開日2013-07-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.353 Å)
主引用文献Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
Proc.Natl.Acad.Sci.USA, 110, 2013
1XFX
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BU of 1xfx by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride
分子名称: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2017-12-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFZ
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BU of 1xfz by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride
分子名称: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
5CJO
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BU of 5cjo by Molmil
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FAB Heavy chain with engineered elbow, FAB light chain, ...
著者liang, w.g, bailey, L, tang, w.j.
登録日2015-07-14
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.287 Å)
主引用文献Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 2017
1YRT
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BU of 1yrt by Molmil
Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin
分子名称: Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin
著者Guo, Q, Shen, Y, Lee, Y.S, Gibbs, C.S, Mrksich, M, Tang, W.J.
登録日2005-02-04
公開日2006-01-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Embo J., 24, 2005
1YRU
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Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride
分子名称: Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin
著者Guo, Q, Shen, Y, Tang, W.J.
登録日2005-02-04
公開日2005-09-27
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
Embo J., 24, 2005

 

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