6KNR
 
 | | Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699 | | Descriptor: | (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol, Estrogen-related receptor gamma | | Authors: | Yoon, H, Kim, J, Chin, J, Song, J, Cho, S.J. | | Deposit date: | 2019-08-07 | | Release date: | 2020-08-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.804 Å) | | Cite: | An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Eur.J.Med.Chem., 205, 2020
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6A6K
 | | Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 | | Descriptor: | 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol, Estrogen-related receptor gamma | | Authors: | Yoon, H, Kim, J, Chin, J, Cho, S.J, Song, J. | | Deposit date: | 2018-06-28 | | Release date: | 2019-04-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
J. Med. Chem., 62, 2019
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2JV5
 | | Nogo54 | | Descriptor: | Reticulon-4 | | Authors: | Li, M, Song, J. | | Deposit date: | 2007-09-12 | | Release date: | 2008-09-16 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structure-based design of buffer-soluble Nogo54: a molecular mimic of Nogo-66 to inhibit CNS neuron regeneration
To be Published
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2KOU
 | | DICER LIKE protein | | Descriptor: | Dicer-like protein 4 | | Authors: | Qin, H, Song, J, Yuan, Y.A. | | Deposit date: | 2009-09-30 | | Release date: | 2010-02-16 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structure of the Arabidopsis thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein-protein interaction
Rna, 2010
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2MDK
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2MP3
 | | Truncated L126Z-sod1 in DPC micelle | | Descriptor: | Superoxide dismutase [Cu-Zn] | | Authors: | Lim, L, Song, J. | | Deposit date: | 2014-05-10 | | Release date: | 2015-05-20 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations
Biochim.Biophys.Acta, 1848, 2015
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5Y70
 | | NMR structure of KMP11 in DPC micelle | | Descriptor: | Kinetoplastid membrane protein 11 | | Authors: | Lu, Y, Lim, L.Z, Song, J. | | Deposit date: | 2017-08-16 | | Release date: | 2018-02-07 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Kinetoplastid membrane protein-11 adopts a four-helix bundle fold in DPC micelle.
FEBS Lett., 591, 2017
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2NAM
 | | Full-length WT SOD1 in DPC MICELLE | | Descriptor: | Superoxide dismutase [Cu-Zn] | | Authors: | Lim, L, Song, J. | | Deposit date: | 2016-01-06 | | Release date: | 2016-12-14 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | SALS-linked WT-SOD1 adopts a highly similar helical conformation as FALS-causing L126Z-SOD1 in a membrane environment
Biochim.Biophys.Acta, 1858, 2016
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2N2C
 | | NMR Structure of TDP-43 prion-like hydrophobic helix in DPC | | Descriptor: | TAR DNA-binding protein 43 | | Authors: | Lim, L, Song, J. | | Deposit date: | 2015-05-06 | | Release date: | 2015-12-02 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | ALS-causing mutations significantly perturb the self-assembly and interaction with nucleic acid of the intrinsically-disordered prion-like domain of TDP-43
To be Published
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5C6D
 | | Crystal structure of USP7 in complex with UHRF1 | | Descriptor: | E3 ubiquitin-protein ligase UHRF1, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Zhang, Z.-M, Song, J. | | Deposit date: | 2015-06-22 | | Release date: | 2015-09-09 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.292 Å) | | Cite: | An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.
Cell Rep, 12, 2015
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7DEB
 | | Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck/Eastern China/L0230/2010 (H5N2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | | Authors: | Sun, H, Sun, H, Song, J, Zhang, W, Qi, J, Gao, G.F, Liu, J. | | Deposit date: | 2020-11-03 | | Release date: | 2021-11-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Haemagglutinin and neuraminidase acid stability in H5N6 avian influenza virus confers infection adaptation in mammals
To Be Published
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7DEA
 | | Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck Northern China/22/2017 (H5N6) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | Authors: | Sun, H, Sun, H, Song, J, Zhang, W, Wei, X, Qi, J, Gao, G.F, Liu, J. | | Deposit date: | 2020-11-03 | | Release date: | 2021-11-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.84 Å) | | Cite: | Haemagglutinin and neuraminidase acid stability in H5N6 avian influenza virus confers infection adaptation in mammals
To Be Published
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5EJX
 | | X-ray Free Electron Laser Structure of Cytochrome C Peroxidase | | Descriptor: | Cytochrome c peroxidase, mitochondrial, PHOSPHATE ION, ... | | Authors: | Doukov, T, Soltis, S.M, Baxter, E.L, Cohen, A, Song, J, McPhillips, S, Poulos, T.L, Meharenna, Y.T, Chreifi, G. | | Deposit date: | 2015-11-02 | | Release date: | 2016-01-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of the pristine peroxidase ferryl center and its relevance to proton-coupled electron transfer.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5EJT
 | | Thermally annealed ferryl Cytochrome C Peroxidase crystal structure | | Descriptor: | Cytochrome c peroxidase, mitochondrial, PHOSPHATE ION, ... | | Authors: | Doukov, T, Soltis, S.M, Baxter, E.L, Cohen, A, Song, J, McPhillips, S, Poulos, T.L, Meharenna, Y.T, Chreifi, G. | | Deposit date: | 2015-11-02 | | Release date: | 2016-01-20 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structure of the pristine peroxidase ferryl center and its relevance to proton-coupled electron transfer.
Proc.Natl.Acad.Sci.USA, 113, 2016
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8JUY
 | | Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state (Class II) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | | Authors: | Cho, C, Song, J. | | Deposit date: | 2023-06-27 | | Release date: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (4.34 Å) | | Cite: | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Commun Biol, 6, 2023
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8JUZ
 | | Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state (Class III) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | | Authors: | Cho, C, Song, J. | | Deposit date: | 2023-06-27 | | Release date: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (4.29 Å) | | Cite: | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Commun Biol, 6, 2023
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8JUW
 | | Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | | Authors: | Cho, C, Song, J. | | Deposit date: | 2023-06-27 | | Release date: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Commun Biol, 6, 2023
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5YX2
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6U90
 | | Crystal structure of DNMT3B(N779A)-DNMT3L in complex with CpGpT DNA | | Descriptor: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | | Authors: | Gao, L, Song, J. | | Deposit date: | 2019-09-06 | | Release date: | 2020-06-10 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.00081754 Å) | | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
To Be Published
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7DAG
 | | Vibrio cholera aldehyde-alcohol dehrogenase | | Descriptor: | Aldehyde-alcohol dehydrogenase | | Authors: | Cho, S, Cho, C, Song, J, Kim, G. | | Deposit date: | 2020-10-16 | | Release date: | 2020-12-30 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.37 Å) | | Cite: | Cryo-EM structure of Vibrio cholerae aldehyde-alcohol dehydrogenase spirosomes.
Biochem.Biophys.Res.Commun., 536, 2020
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7WJ5
 | | Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity | | Descriptor: | Gai1 antibody (scfv16), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Heo, Y.S, Yoon, E.J, Jeon, Y.E, Yun, J.-H, Ishimoto, N, Woo, H, Park, S.Y, Song, J, Lee, W.T. | | Deposit date: | 2022-01-05 | | Release date: | 2022-07-13 | | Method: | ELECTRON MICROSCOPY (3.72 Å) | | Cite: | Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity.
Elife, 11, 2022
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6U91
 | | Crystal structure of DNMT3B(Q772R)-DNMT3L in complex with CpGpT DNA | | Descriptor: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | | Authors: | Gao, L, Song, J. | | Deposit date: | 2019-09-06 | | Release date: | 2020-06-10 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.99998879 Å) | | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
To Be Published
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7E4K
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7CRN
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7DXO
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