6KNR

Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699

Summary for 6KNR

• Entry DOI: 10.2210/pdb6knr/pdb
• Descriptor: Estrogen-related receptor gamma, (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol (3 entities in total)
• Functional Keywords: estrogen-related receptor gamma, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 55747.14

Authors

Yoon, H.,Kim, J.,Chin, J.,Song, J.,Cho, S.J. (deposition date: 2019-08-07, release date: 2020-08-12, Last modification date: 2023-11-22)

• Primary citation: Kim, J.,Hwang, H.,Yoon, H.,Lee, J.E.,Oh, J.M.,An, H.,Ji, H.D.,Lee, S.,Cha, E.,Ma, M.J.,Kim, D.S.,Lee, S.J.,Kadayat, T.M.,Song, J.,Lee, S.W.,Jeon, J.H.,Park, K.G.,Lee, I.K.,Jeon, Y.H.,Chin, J.,Cho, S.J.; An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.; Eur.J.Med.Chem., 205:112501-112501, 2020; PubMed: 32758860; DOI: 10.1016/j.ejmech.2020.112501

Experimental method

X-RAY DIFFRACTION (2.804 Å)