2N2C

NMR Structure of TDP-43 prion-like hydrophobic helix in DPC

Summary for 2N2C

• Entry DOI: 10.2210/pdb2n2c/pdb
• NMR Information: BMRB: 25595
• Descriptor: TAR DNA-binding protein 43 (1 entity in total)
• Functional Keywords: als, prion-like domain, hydrophobic helices, membrane interaction, dpc, tar dna-binding protein-43, dna binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q13148
• Total number of polymer chains: 1
• Total formula weight: 4336.97

Authors

Lim, L.,Song, J. (deposition date: 2015-05-06, release date: 2015-12-02, Last modification date: 2023-06-14)

• Primary citation: Lim, L.,Song, J.; ALS-causing mutations significantly perturb the self-assembly and interaction with nucleic acid of the intrinsically-disordered prion-like domain of TDP-43; To be Published,

Experimental method

SOLUTION NMR