4R7A
| Crystal Structure of RBBP4 bound to PHF6 peptide | Descriptor: | GLYCEROL, Histone-binding protein RBBP4, PHD finger protein 6 | Authors: | Liu, Z, Li, F, Zhang, B, Li, S, Wu, J, Shi, Y. | Deposit date: | 2014-08-27 | Release date: | 2015-01-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by the Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex J.Biol.Chem., 290, 2015
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4RHW
| Crystal structure of Apaf-1 CARD and caspase-9 CARD complex | Descriptor: | Apoptotic protease-activating factor 1, CHLORIDE ION, Caspase-9, ... | Authors: | Hu, Q, Wu, D, Yan, C, Shi, Y. | Deposit date: | 2014-10-03 | Release date: | 2014-10-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome. Proc. Natl. Acad. Sci. U.S.A., 111, 2014
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4GUR
| Crystal structure of LSD2-NPAC with H3 in space group P21 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... | Authors: | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | Deposit date: | 2012-08-29 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.506 Å) | Cite: | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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4GUS
| Crystal structure of LSD2-NPAC with H3 in space group P3221 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... | Authors: | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | Deposit date: | 2012-08-29 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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4GUT
| Crystal structure of LSD2-NPAC | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1B, ... | Authors: | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | Deposit date: | 2012-08-29 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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4GU1
| Crystal structure of LSD2 | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1B, ... | Authors: | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | Deposit date: | 2012-08-29 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.939 Å) | Cite: | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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7Y5X
| CryoEM structure of PS2-containing gamma-secretase treated with MRK-560 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. | Deposit date: | 2022-06-17 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560. Nat Commun, 13, 2022
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7Y5T
| CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. | Deposit date: | 2022-06-17 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560. Nat Commun, 13, 2022
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7Y5Z
| CryoEM structure of human PS2-containing gamma-secretase | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. | Deposit date: | 2022-06-18 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560. Nat Commun, 13, 2022
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8JNS
| cryo-EM structure of a CED-4 hexamer | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION | Authors: | Li, Y, Shi, Y. | Deposit date: | 2023-06-06 | Release date: | 2023-06-28 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural insights into CED-3 activation. Life Sci Alliance, 6, 2023
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8JO0
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8A9L
| Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies | Descriptor: | Alpha-synuclein, Unknown fragment | Authors: | Yang, Y, Shi, Y, Schweighauser, M, Zhang, X.J, Kotecha, A, Murzin, A.G, Garringer, H.J, Cullinane, P, Saito, Y, Foroud, T, Warner, T.T, Hasegawa, K, Vidal, R, Murayama, S, Revesz, T, Ghetti, B, Hasegawa, M, Lashley, T, Scheres, H.W.S, Goedert, M. | Deposit date: | 2022-06-28 | Release date: | 2022-08-31 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structures of alpha-synuclein filaments from human brains with Lewy pathology. Nature, 610, 2022
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5B88
| RRM-like domain of DEAD-box protein, CsdA | Descriptor: | ATP-dependent RNA helicase DeaD | Authors: | Xu, L, Peng, J, Zhang, J, Wu, J, Tang, Y, Shi, Y. | Deposit date: | 2016-06-13 | Release date: | 2017-05-31 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions. Structure, 25, 2017
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5CJB
| Human Osteoclast Associated Receptor (OSCAR) in complex with a collagen-like peptide | Descriptor: | Osteoclast-associated immunoglobulin-like receptor, collagen-like peptide | Authors: | Gao, G.F, Qi, J, Shi, Y, Haywood, J. | Deposit date: | 2015-07-14 | Release date: | 2016-01-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.398 Å) | Cite: | Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors. Proc.Natl.Acad.Sci.USA, 113, 2016
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4YDO
| CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE IN APO FORM | Descriptor: | CALCIUM ION, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Uncharacterized protein, ... | Authors: | Kumar, S, Mabanglo, M.F, Hast, M.A, Shi, Y, Beese, L.S. | Deposit date: | 2015-02-22 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE IN APO FORM To Be Published
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3F4M
| Crystal structure of TIPE2 | Descriptor: | CHLORIDE ION, Tumor necrosis factor, alpha-induced protein 8-like protein 2 | Authors: | Zhang, X, Wang, J, Shi, Y. | Deposit date: | 2008-11-01 | Release date: | 2009-03-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.696 Å) | Cite: | Crystal structure of TIPE2 provides insights into immune homeostasis Nat.Struct.Mol.Biol., 16, 2009
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7N9A
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5CJ8
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4Y6K
| Complex structure of presenilin homologue PSH bound to an inhibitor | Descriptor: | N-{(2R,4S,5S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-leucyl-L-phenylalaninamide, Uncharacterized protein PSH | Authors: | Dang, S, Wu, S, Wang, J, Shi, Y. | Deposit date: | 2015-02-13 | Release date: | 2015-03-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.855 Å) | Cite: | Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH Proc.Natl.Acad.Sci.USA, 112, 2015
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4NN2
| Protein Crystal Structure of Human Borjeson-Forssman-Lehmann Syndrome Associated Protein PHF6 | Descriptor: | GLYCEROL, PHD finger protein 6, ZINC ION | Authors: | Liu, Z, Li, F, Zhang, J, Mei, Y, Wu, J, Shi, Y. | Deposit date: | 2013-11-16 | Release date: | 2014-02-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.472 Å) | Cite: | Crystal Structure of the second extended PHD domain of human PHF6 protein J.Biol.Chem., 2014
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4YDE
| CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE BINARY COMPLEX WITH THE ISOPRENOID FARNESYLDIPHOSPHATE | Descriptor: | (3R,7S)-3,7,11-trimethyldodecyl trihydrogen diphosphate, 1,2-ETHANEDIOL, Protein farnesyltransferase/geranylgeranyltransferase type-1 Subunit beta, ... | Authors: | Kumar, S, Mabanglo, M.F, Hast, M.A, Shi, Y, Beese, L.S. | Deposit date: | 2015-02-22 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE BINARY COMPLEX WITH THE ISOPRENOID FARNESYLDIPHOSPHATE To Be Published
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5A63
| Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Bai, X, Yan, C, Yang, G, Lu, P, Ma, D, Sun, L, Zhou, R, Scheres, S.H.W, Shi, Y. | Deposit date: | 2015-06-24 | Release date: | 2015-08-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | An Atomic Structure of Human Gamma-Secretase Nature, 525, 2015
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4M38
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4N40
| Crystal structure of human Epithelial cell-transforming sequence 2 protein | Descriptor: | Protein ECT2 | Authors: | Zou, Y, Shao, Z.H, Li, F.D, Gong, D, Wang, C, Gong, Q, Shi, Y. | Deposit date: | 2013-10-08 | Release date: | 2014-08-27 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3.106 Å) | Cite: | Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 Febs Lett., 588, 2014
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5IY3
| Zika Virus Non-structural Protein NS1 | Descriptor: | Genome polyprotein | Authors: | Song, H, Qi, J, Shi, Y, Gao, G.F. | Deposit date: | 2016-03-23 | Release date: | 2016-04-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses Nat.Struct.Mol.Biol., 23, 2016
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