Crystal structure of Apaf-1 CARD and caspase-9 CARD complex

Summary for 4RHW

DescriptorApoptotic protease-activating factor 1, Caspase-9, SULFATE ION, ... (5 entities in total)
Functional Keywordsdeath domain superfamily, apoptosis
Biological sourceHomo sapiens (human)
Total number of polymer chains6
Total molecular weight70625.29
Hu, Q.,Wu, D.,Yan, C.,Shi, Y. (deposition date: 2014-10-03, release date: 2014-10-15, Last modification date: 2018-10-17)
Primary citation
Hu, Q.,Wu, D.,Chen, W.,Yan, Z.,Yan, C.,He, T.,Liang, Q.,Shi, Y.
Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.
Proc. Natl. Acad. Sci. U.S.A., 111:16254-16261, 2014
PubMed: 25313070 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1418000111
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23011 0.2% 6.0% 2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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