4RHW
Crystal structure of Apaf-1 CARD and caspase-9 CARD complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Apoptotic protease-activating factor 1 | polymer | 97 | 11099.7 | 4 | UniProt (O14727) Pfam (PF00619) | Homo sapiens (human) | APAF-1 |
| 2 | E, F (E, F) | Caspase-9 | polymer | 108 | 12741.5 | 2 | UniProt (P55211) Pfam (PF00619) | Homo sapiens (human) | CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, ICE-like apoptotic protease 6, ICE-LAP6, Caspase-9 subunit p35, Caspase-9 subunit p10 |
| 3 | G, H, I, J, L... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 4 | K, O (B, D) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | P, Q, R, S, T... (A, B, C, D, E...) | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence modifications
E, F: 1 - 100 (UniProt: P55211)
| PDB | External Database | Details |
|---|---|---|
| Leu 101 | - | expression tag |
| Glu 102 | - | expression tag |
| His 103 | - | expression tag |
| His 104 | - | expression tag |
| His 105 | - | expression tag |
| His 106 | - | expression tag |
| His 107 | - | expression tag |
| His 108 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 69881.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 743.3 | |
| All* | Total formula weight | 70625.3 |
