4GUS

Crystal structure of LSD2-NPAC with H3 in space group P3221

Summary for 4GUS

• Entry DOI: 10.2210/pdb4gus/pdb
• Related: 4GU1 4GUR 4GUT
• Descriptor: Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, Histone H3.3, ... (8 entities in total)
• Functional Keywords: histone demethylase, oxidoreductase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (By similarity): Q8NB78; Nucleus: Q49A26 P84243
• Total number of polymer chains: 3
• Total formula weight: 104770.87

Authors

Chen, F.,Dong, Z.,Fang, J.,Yang, Y.,Li, Z.,Xu, Y.,Yang, H.,Wang, P.,Fang, R.,Shi, Y.,Xu, Y. (deposition date: 2012-08-29, release date: 2013-01-16, Last modification date: 2023-11-08)

• Primary citation: Fang, R.,Chen, F.,Dong, Z.,Hu, D.,Barbera, A.J.,Clark, E.A.,Fang, J.,Yang, Y.,Mei, P.,Rutenberg, M.,Li, Z.,Zhang, Y.,Xu, Y.,Yang, H.,Wang, P.,Simon, M.D.,Zhou, Q.,Li, J.,Marynick, M.P.,Li, X.,Lu, H.,Kaiser, U.B.,Kingston, R.E.,Xu, Y.,Shi, Y.G.; LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation; Mol.Cell, 49:558-570, 2013; PubMed: 23260659; DOI: 10.1016/j.molcel.2012.11.019

Experimental method

X-RAY DIFFRACTION (2.23 Å)