4GUS
Crystal structure of LSD2-NPAC with H3 in space group P3221
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Lysine-specific histone demethylase 1B | polymer | 776 | 87051.5 | 1 | UniProt (Q8NB78) Pfam (PF07496) Pfam (PF04433) Pfam (PF01593) In PDB | Homo sapiens (human) | LSD2, Flavin-containing amine oxidase domain-containing protein 1, Lysine-specific histone demethylase 2 |
2 | B | Putative oxidoreductase GLYR1 | polymer | 124 | 13528.3 | 1 | UniProt (Q49A26) In PDB | Homo sapiens (human) | NPAC, 3-hydroxyisobutyrate dehydrogenase-like protein, Cytokine-like nuclear factor N-PAC, Glyoxylate reductase 1 homolog, Nuclear protein NP60, Nuclear protein of 60 kDa |
3 | C | Histone H3.3 | polymer | 21 | 2263.7 | 1 | UniProt (P84243) In PDB | Homo sapiens | H3 |
4 | A | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
5 | A | IODIDE ION | non-polymer | 126.9 | 6 | Chemie (IOD) | |||
6 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
7 | A | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
8 | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A: 51 - 822 (UniProt: Q8NB78)
B: 152 - 268 (UniProt: Q49A26)
C: 1 - 21 (UniProt: P84243)
PDB | External Database | Details |
---|---|---|
Pro 47 | - | expression tag |
Leu 48 | - | expression tag |
Gly 49 | - | expression tag |
Ser 50 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro 145 | - | expression tag |
Leu 146 | - | expression tag |
Gly 147 | - | expression tag |
Ser 148 | - | expression tag |
Pro 149 | - | expression tag |
Glu 150 | - | expression tag |
Phe 151 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 4 | Lys 5 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 102843.5 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1927.4 | |
All* | Total formula weight | 104770.9 |