8A9L

Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies

Summary for 8A9L

Entry DOI	10.2210/pdb8a9l/pdb
EMDB information	15285
Descriptor	Alpha-synuclein, Unknown fragment, ... (4 entities in total)
Functional Keywords	alpha-synuclein, amyloid, fibril, parkinson's disease (pd), parkinson's disease dementia (pdd), dementia with lewy bodies (dlb), synucleinopathy, protein fibril
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	15887.84
Authors	Yang, Y.,Shi, Y.,Schweighauser, M.,Zhang, X.J.,Kotecha, A.,Murzin, A.G.,Garringer, H.J.,Cullinane, P.,Saito, Y.,Foroud, T.,Warner, T.T.,Hasegawa, K.,Vidal, R.,Murayama, S.,Revesz, T.,Ghetti, B.,Hasegawa, M.,Lashley, T.,Scheres, H.W.S.,Goedert, M. (deposition date: 2022-06-28, release date: 2022-08-31, Last modification date: 2022-11-09)
Primary citation	Yang, Y.,Shi, Y.,Schweighauser, M.,Zhang, X.,Kotecha, A.,Murzin, A.G.,Garringer, H.J.,Cullinane, P.W.,Saito, Y.,Foroud, T.,Warner, T.T.,Hasegawa, K.,Vidal, R.,Murayama, S.,Revesz, T.,Ghetti, B.,Hasegawa, M.,Lashley, T.,Scheres, S.H.W.,Goedert, M. Structures of alpha-synuclein filaments from human brains with Lewy pathology. Nature, 610:791-795, 2022 Cited by PubMed: 36108674 DOI: 10.1038/s41586-022-05319-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.16 Å)

Structure validation