5IY3

Zika Virus Non-structural Protein NS1

Summary for 5IY3

• Entry DOI: 10.2210/pdb5iy3/pdb
• Descriptor: Genome polyprotein (2 entities in total)
• Functional Keywords: flavivirus, viral protein
• Biological source: Zika virus (ZIKV)
• Cellular location: Virion membrane ; Multi-pass membrane protein : A0A024B7W1
• Total number of polymer chains: 2
• Total formula weight: 41533.03

Authors

Song, H.,Qi, J.,Shi, Y.,Gao, G.F. (deposition date: 2016-03-23, release date: 2016-04-13, Last modification date: 2024-10-16)

Primary citation

Song, H.,Qi, J.,Haywood, J.,Shi, Y.,Gao, G.F.
Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses
Nat.Struct.Mol.Biol., 23:456-458, 2016

PubMed Abstract: The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly implying different modes of flavivirus pathogenesis.

PubMed: 27088990
DOI: 10.1038/nsmb.3213

Experimental method

X-RAY DIFFRACTION (2.2 Å)