7Y5T

CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560

Summary for 7Y5T

• Entry DOI: 10.2210/pdb7y5t/pdb
• EMDB information: 33624
• Descriptor: Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total)
• Functional Keywords: intramembrane protease, gamma-secretase, presenilin-1, membrane protein, membrane protein-hydrolase complex, membrane protein/hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 179871.32

Authors

Guo, X.,Wang, Y.,Zhou, J.,Jin, C.,Wang, J.,Jia, B.,Jing, D.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y. (deposition date: 2022-06-17, release date: 2022-11-02)

• Primary citation: Guo, X.,Wang, Y.,Zhou, J.,Jin, C.,Wang, J.,Jia, B.,Jing, D.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y.; Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.; Nat Commun, 13:6299-6299, 2022; PubMed: 36272978; DOI: 10.1038/s41467-022-33817-5

Experimental method

ELECTRON MICROSCOPY (2.9 Å)